DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bin and Foxa2

DIOPT Version :9

Sequence 1:	NP_523950.2	Gene:	bin / 38766	FlyBaseID:	FBgn0045759	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_006235201.1	Gene:	Foxa2 / 25099	RGDID:	2808	Length:	465	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	128/458 - (27%)
Similarity:	184/458 - (40%)	Gaps:	102/458 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 SPGGGYMSRISTSPSQVISNAHGMPVLN-YSSSSSSP-----AKSLNGSESSPPSQNHLENKVSG 280
            |||.|.|:.:|.|     :.|.|:..:. :.|.|.||     |.::.|  .:|     ..|..|.
  Rat    87 SPGAGAMAGMSGS-----AGAAGVAGMGPHLSPSLSPLGGQAAGAMGG--LAP-----YANMNSM 139

  Fly   281 SAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSY 345
            |.:.|..|.|:   ...|.|.::|.|.  .||..|||::|..||::||...|||||||.::...:
  Rat   140 SPMYGQAGLSR---ARDPKTYRRSYTH--AKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLF 199

  Fly   346 EFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRRPR-G 409
            .|:|.....|:||:||:||.|:||.|:|:  ...|||||::||:..:|.::||:...|||:.| .
  Rat   200 PFYRQNQQRWQNSIRHSLSFNDCFLKVPR--SPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFK 262

  Fly   410 YRSKIKVKPYAGHANGYYASGYGDAGMDNGNYYASPAFASYDY--SAAGATGVSPAGGQGFADPW 472
            ...::.:|..||            ||...|...|....||...  .|||:...:|||
  Rat   263 CEKQLALKEAAG------------AGSGGGKKTAPGTQASQVQLGEAAGSASETPAG-------- 307

  Fly   473 NAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGG-----NVNGSATTPPLAHSALGMAPSASSSS 532
             ..:.||.:|         |..::..      ||     ....||.:||        .|:.|...
  Rat   308 -TESPHSSAS---------PCQEHKR------GGLSELKGTPASALSPP--------EPAPSPGQ 348

  Fly   533 SPLGAAATLQSDY---APTASLVAAGYSYATSAGSLDNGLRSISLQQLPGLSSIQHAQAQAQAQA 594
            ....||..|...:   .|..:.:...:.||.:.....|.|.|                   ..|.
  Rat   349 QQQAAAHLLVPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMS-------------------SEQQ 394

  Fly   595 HHHHHQHHASHPSHSHQGHGSMHQNHGTSSTTPPPSQSG---GSHGIDHSPIDRKPAYLPPISPP 656
            |||.|.||..|..........||...|..|..|.....|   ...|:|.||:....:|...:...
  Rat   395 HHHSHHHHQPHKMDLKTYEQVMHYPGGYGSPMPGSLAMGPVTNKAGLDASPLAADTSYYQGVYSR 459

  Fly   657 PMM 659
            |:|
  Rat   460 PIM 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	Forkhead	311..399	CDD:278670	40/87 (46%)
Foxa2	XP_006235201.1	Forkhead_N	23..164	CDD:254796	26/93 (28%)
		FH	165..253	CDD:214627	41/89 (46%)
		HNF_C	381..454	CDD:286443	22/91 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910