DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bin and Foxa1

DIOPT Version :9

Sequence 1:	NP_523950.2	Gene:	bin / 38766	FlyBaseID:	FBgn0045759	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_038967720.1	Gene:	Foxa1 / 25098	RGDID:	2807	Length:	475	Species:	Rattus norvegicus

Alignment Length:	391	Identity:	105/391 - (26%)
Similarity:	167/391 - (42%)	Gaps:	63/391 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 NHQYASTIKYCSN----------NTILSANDYQLLTSQEQAGQQQPQQ-------------LPAQ 217
            |..||.|.:..|:          .::.|.|.|..:.:...:|...|..             |...
  Rat    16 NSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMTPASFNMSYANPGLGAGLSPG 80

  Fly   218 QLQHSPGGGYMSRISTSPSQVISNAHGMPVLNYSSSSSSPAKSLNGSESSPPSQNHLENKVS--- 279
            .:...|||...:..|.:.:.|.:....:......|..:.||.|:||......:.|...:.::
  Rat    81 AVAGMPGGSAGAMNSMTAAGVTAMGAALSPGGMGSMGAQPAASMNGLGPYAAAMNPCMSPMAYAP 145

  Fly   280 ---GSAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYL 341
               |.:..|.||.::....|.|..          ||..|||::|..||:::|:..|||||||.::
  Rat   146 SNLGRSRAGGGGDAKTFKRSYPHA----------KPPYSYISLITMAIQQAPSKMLTLSEIYQWI 200

  Fly   342 QKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRR 406
            ...:.::|.....|:||:||:||.|:||.|:.:  ...|||||:|||:..:|.::||:...|||:
  Rat   201 MDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVAR--SPDKPGKGSYWTLHPDSGNMFENGCYLRRQ 263

  Fly   407 PRGYRSKIKVKPYAGHANGYYASGYGDAGM-DNGNYYASPAFASYD-------YSAAGATGVSPA 463
            .   |.|.:.:|.||..:|    |.|..|: :|....:.|...|.:       :..|.....:||
  Rat   264 K---RFKCEKQPGAGGGSG----GGGSKGVPENRKDPSGPVNPSAESPIHRGVHGKASQLEGAPA 321

  Fly   464 GGQGFADPWNAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGGNVNGSATTPPLAHSALGMAPSA 528
            .|.. |.|....  |||:::.|   |...|....:.|...........|:.|| :|.|.|:||..
  Rat   322 PGPA-ASPQTLD--HSGATATG---GASELKSPASSSAPPISSGPGALASVPP-SHPAHGLAPHE 379

  Fly   529 S 529
            |
  Rat   380 S 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	Forkhead	311..399	CDD:278670	38/87 (44%)
Foxa1	XP_038967720.1	Forkhead_N	17..169	CDD:369872	28/151 (19%)
		FH_FOXA1	157..268	CDD:410812	46/125 (37%)
		HNF_C	394..457	CDD:401339
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910