Protein Alignment bin and Foxg1

DIOPT Version :10

• Sequence 1: NP_523950.2
• Gene: bin / 38766
• FlyBaseID: FBgn0045759
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_036692.1
• Gene: Foxg1 / 24370
• RGDID: 2619
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 676
• Identity: 150/676 - (22%)
• Similarity: 217/676 - (32%)
• Gaps: 237/676 - (35%)

  Fly     1 MIKSEEASDRSVMTMDQLGGYYHDPRAHPPFSHPHAHSHPHQHTHTGHPYRAGNLLTGGNYQAMG 65
            ||.....|..|::........:|....|....||..|.|.|.|.|
  Rat    12 MIPKSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHH-------------------- 56

  Fly    66 GGESPTELIDEKPNIGYMELKHYMDATPTATPVSAAQHYSLSALHSMGTPPASSSPIPPYGVLMT 130
                                                            .||.:..|.||
  Rat    57 ------------------------------------------------PPPPAPQPPPP------ 67

  Fly   131 AHSAGSASPQSNSKTPTDLPQDLQYASSSTSTAKVQPLQVQLQPLNHQYASTIKYCSNNTILSAN 195
                    |....:.|...||..|...:..:.....|     |||
  Rat    68 --------PPQQQQQPPPAPQPPQARGAPAADDDKGP-----QPL-------------------- 99

  Fly   196 DYQLLTSQEQAGQQQPQQLPAQQLQHSPGGGYMSRISTSPSQVISNAHGMPVLNYSSSSSSPAKS 260
               ||.........:...|.|   :..||||........|.:....|..
  Rat   100 ---LLPPSAALDGAKADALGA---KGEPGGGPAELAPVGPDEKEKGAGA---------------- 142

  Fly   261 LNGSESSPPSQNHLENKVSGSAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIK 325
              |.|         |.|.:|.     ||   :|.....:..||:|  :.|||..||..:|..||:
  Rat   143 --GGE---------EKKGAGE-----GG---KDGEGGKEGDKKNG--KYEKPPFSYNALIMMAIR 186

  Fly   326 ESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTID 390
            :||..:|||:.||.::.|::.::|....||:||:|||||||:||.|:|:  ....|||||||.:|
  Rat   187 QSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPR--HYDDPGKGNYWMLD 249

  Fly   391 ENSAHLF--EDEGSLRRRPRGYRSKIKVKPYAGHANGYYASGYGDAGMDNGN--YYASPAFASYD 451
            .:|..:|  ...|.||||....|:|:..|      .|...:..|...||...  |:....|.|..
  Rat   250 PSSDDVFIGGTTGKLRRRSTTSRAKLAFK------RGARLTSTGLTFMDRAGSLYWPMSPFLSLH 308

  Fly   452 YSAAGATGVSPAGGQGFADPWNAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGGNVNGSATTPP 516
            :..|.:|       ..:....:|:.:|             |:| |:::....:.||.:..:|...
  Rat   309 HPRASST-------LSYNGTTSAYPSH-------------PMP-YSSVLTQNSLGNNHSFSTANG 352

  Fly   517 LAHSAL--GMAPSASSSSSPLGAAATLQSDYAPTASLVAAGYSYATSAGSLDNGLRSISLQQLPG 579
            |:...|  |..|.|:...:....||::     |....|....:|:         |...|:..|.|
  Rat   353 LSVDRLVNGEIPYATHHLTAAALAASV-----PCGLSVPCSGTYS---------LNPCSVNLLAG 403

  Fly   580 LSSIQHAQAQAQAQAHHHHHQHHASHPSHSHQGHGSMHQNHGTSSTTPPPSQSGGSHGIDHSPID 644
            .:|               :...|..|||.:.|...||.....:|||:|
  Rat   404 QTS---------------YFFPHVPHPSMTSQTSTSMSARAASSSTSP----------------- 436

  Fly   645 RKPAYLP-----PISPPPMMVALNGG 665
            :.|:.||     | |.|.....|:||
  Rat   437 QAPSTLPCESLRP-SLPSFTTGLSGG 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	FH_FOX	312..391	CDD:469596	37/78 (47%)
Foxg1	NP_036692.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..172		44/290 (15%)
		FH_FOXG	172..250	CDD:410795	38/79 (48%)
		COG5025	<175..>347	CDD:227358	63/200 (32%)
		Required for interaction with TLE6. /evidence=ECO:0000250|UniProtKB:Q60987	240..335		32/121 (26%)
		Interaction with KDM5B. /evidence=ECO:0000250	374..397		6/36 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	418..446		10/44 (23%)