Protein Alignment bin and FOXC2

DIOPT Version :9

• Sequence 1: NP_523950.2
• Gene: bin / 38766
• FlyBaseID: FBgn0045759
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_005242.1
• Gene: FOXC2 / 2303
• HGNCID: 3801
• Length: 501
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 136/520 - (26%)
• Similarity: 193/520 - (37%)
• Gaps: 139/520 - (26%)

  Fly   239 ISNAHGMPVLNY-SSSSSSPAKSLNGSESSPPS--QNHLENKVSGSAVVGTGGSS----QQDAPS 296
            :|:.:.:.|:.| |..:...|....|..:||..  ..|.|...:|.      |.|    ....|:
Human     7 VSDPNALGVVPYLSEQNYYRAAGSYGGMASPMGVYSGHPEQYSAGM------GRSYAPYHHHQPA 65

  Fly   297 TPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRH 361
            .|        :...||..|||.:|..||:.:|..|:||:.||.::...:.|:|....||:||:||
Human    66 AP--------KDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRH 122

  Fly   362 NLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRRPR----------GYRSKIKV 416
            ||||||||.|:|:  ...|||||:|||:|.:|.::||:...||||.|          ..|:.:|.
Human   123 NLSLNECFVKVPR--DDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVSKEKEERAHLKE 185

  Fly   417 KPYAGHANGYYASGYGDAGMDN------GNYYASPAF--------ASYDYSAAG---ATGVSPAG 464
            .|.|............||..:.      .:..||||.        .|.:.:..|   :...:|||
Human   186 PPPAASKGAPATPHLADAPKEAEKKVVIKSEAASPALPVITKVETLSPESALQGSPRSAASTPAG 250

  Fly   465 GQGFADPWNAHAAHSGSSSVGVGMGVGPLPQYT--NISCLAA---GGNVNGSA-----TTPPLAH 519
            ....:.|.:..||.:|            ||.::  ||..|..   ||.::..|     ..||||.
Human   251 SPDGSLPEHHAAAPNG------------LPGFSVENIMTLRTSPPGGELSPGAGRAGLVVPPLAL 303

  Fly   520 SALGMAPSASSSSSPLGAAATLQSDYAPTASLVAAGYSYATSAGSLDNGLRSISLQQLP------ 578
            ......|:|.......|..|.           .|.||..:..|.||..|....:...:|
Human   304 PYAAAPPAAYGQPCAQGLEAG-----------AAGGYQCSMRAMSLYTGAERPAHMCVPPALDEA 357

  Fly   579 ----------GLSSIQHAQAQAQA-QAHHHHHQHHASH------------------PSHSHQGHG 614
                      .||::..|..|..| .|..||||||..|                  |..:.....
Human   358 LSDHPSGPTSPLSALNLAAGQEGALAATGHHHQHHGHHHPQAPPPPPAPQPQPTPQPGAAAAQAA 422

  Fly   615 SMHQNH-------------GTSSTTPPPSQSGGSH--GIDHSPIDRK------PAYLPPISPPPM 658
            |.:.||             ....|.|...:...||  ||::|.:...      ...||..|.||:
Human   423 SWYLNHSGDLNHLPGHTFAAQQQTFPNVREMFNSHRLGIENSTLGESQVSGNASCQLPYRSTPPL 487

  Fly   659  658
            Human   488  487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	Forkhead	311..399	CDD:278670	43/87 (49%)
FOXC2	NP_005242.1	FH	72..160	CDD:214627	44/89 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..208		7/40 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	232..268		9/47 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..420		9/36 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910