DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bin and FOXG1

DIOPT Version :9

Sequence 1:	NP_523950.2	Gene:	bin / 38766	FlyBaseID:	FBgn0045759	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_005240.3	Gene:	FOXG1 / 2290	HGNCID:	3811	Length:	489	Species:	Homo sapiens

Alignment Length:	695	Identity:	157/695 - (22%)
Similarity:	227/695 - (32%)	Gaps:	266/695 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIKSEEASDRSVMTMDQLGGYYHDPRAHPPFSHPHAHSHPHQHTHTGHPYRAGNLLTGGNYQAMG 65
            ||.....|..|::........:|....|....||..|.|.|.|.|  ||
Human    12 MIPKSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHH--HP---------------- 58

  Fly    66 GGESPTELIDEKPNIGYMELKHYMDATPTATPVSAAQHYSLSALHSMGTPPASSSPIPPYGVLMT 130
                                                             ||.:..|.||
Human    59 -------------------------------------------------PPPAPQPPPP------ 68

  Fly   131 AHSAGSASPQSNSKTPTDLPQDLQYASSSTSTAKVQPLQVQLQPLNHQYASTIKYCSNNTILSAN 195
                    ||.....|...|..             ||.|.:..|                  :|:
Human    69 --------PQQQQPPPPPPPAP-------------QPPQTRGAP------------------AAD 94

  Fly   196 DYQLLTSQEQAGQQQPQQL---------PAQQL----------QHSPGGGYMSRISTSPSQVISN 241
            |           .:.||||         ||..|          :..||||        |.::
Human    95 D-----------DKGPQQLLLPPPPPPPPAAALDGAKADGLGGKGEPGGG--------PGEL--- 137

  Fly   242 AHGMPVLNYSSSSSSPAKSLNGSESSPPSQNHLENKVSGSAVVGTGGSSQQDAPSTPDTTKKSGT 306
               .||        .|.:...|:.:..      |.|..    .|.||   :|.....:..||:|
Human   138 ---APV--------GPDEKEKGAGAGG------EEKKG----AGEGG---KDGEGGKEGEKKNG- 177

  Fly   307 RRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKK 371
             :.|||..||..:|..||::||..:|||:.||.::.|::.::|....||:||:|||||||:||.|
Human   178 -KYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVK 241

  Fly   372 LPKGMGVGKPGKGNYWTIDENSAHLF--EDEGSLRRRPRGYRSKIKVKPYAGHANGYYASGYGDA 434
            :|:  ....|||||||.:|.:|..:|  ...|.||||....|:|:..|      .|...:..|..
Human   242 VPR--HYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFK------RGARLTSTGLT 298

  Fly   435 GMDNGN--YYASPAFASYDYSAAGATGVSPAGGQGFADPWNAHAAHSGSSSVGVGMGVGPLPQYT 497
            .||...  |:....|.|..:..|.:|       ..:....:|:.:|             |:| |:
Human   299 FMDRAGSLYWPMSPFLSLHHPRASST-------LSYNGTTSAYPSH-------------PMP-YS 342

  Fly   498 NISCLAAGGNVNGSATTPPLAHSAL--GMAPSASSSSSPLGAAATLQSDYAPTASLVAAGYSYAT 560
            ::....:.||.:..:|...|:...|  |..|.|:...:....||::     |....|....:|:
Human   343 SVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAALAASV-----PCGLSVPCSGTYS- 401

  Fly   561 SAGSLDNGLRSISLQQLPGLSSIQHAQAQAQAQAHHHHHQHHASHPSHSHQGHGSMHQNHGTSST 625
                    |...|:..|.|.:|               :...|..|||.:.|...||.....:|||
Human   402 --------LNPCSVNLLAGQTS---------------YFFPHVPHPSMTSQSSTSMSARAASSST 443

  Fly   626 TPPPSQSGGSHGIDHSPIDRKPAYLP-----PISPPPMMVALNGG 665
            :|                 :.|:.||     | |.|.....|:||
Human   444 SP-----------------QAPSTLPCESLRP-SLPSFTTGLSGG 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	Forkhead	311..399	CDD:278670	41/89 (46%)
FOXG1	NP_005240.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..181		51/309 (17%)
		FH_FOXG	181..259	CDD:410795	38/79 (48%)
		COG5025	<184..>356	CDD:227358	63/200 (32%)
		Required for interaction with TLE6. /evidence=ECO:0000250\|UniProtKB:Q60987	249..344		32/121 (26%)
		Interaction with KDM5B. /evidence=ECO:0000269\|PubMed:12657635	383..406		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..455		10/44 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810