DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bin and FOXK1

DIOPT Version :9

Sequence 1:	NP_523950.2	Gene:	bin / 38766	FlyBaseID:	FBgn0045759	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001032242.1	Gene:	FOXK1 / 221937	HGNCID:	23480	Length:	733	Species:	Homo sapiens

Alignment Length:	602	Identity:	145/602 - (24%)
Similarity:	214/602 - (35%)	Gaps:	167/602 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ATPTATPVSAAQHYSLSALHSMGTPPASSSPIPPYGVLMTAHSAGSASPQSNSKTPTDLPQDLQY 155
            |...|.|.:|............|.||....|:|| |.:..|.|:|.:|..|...........|..
Human    29 AAAAAFPAAAPPPAPAQPQPPPGPPPPPPPPLPP-GAIAGAGSSGGSSGVSGDSAVAGAAPALVA 92

  Fly   156 ASSSTSTAKVQPLQVQLQP-----LNHQYASTIKYCSN----------NTILSANDYQLLTSQ-- 203
            |::::......|...:|:.     |..|.:.||...|:          ::.:|....||...:
Human    93 AAAASVRQSPGPALARLEGREFEFLMRQPSVTIGRNSSQGSVDLSMGLSSFISRRHLQLSFQEPH 157

  Fly   204 -----------------EQAGQ---QQPQQ----------------------LPAQQLQ------ 220
                             ::.|.   |.|:|                      .||..|:
Human   158 FYLRCLGKNGVFVDGAFQRRGAPALQLPKQCTFRFPSTAIKIQFTSLYHKEEAPASPLRPLYPQI 222

  Fly   221 -----HSPGGGYMSRISTSPSQVISNAHGMPVLNYSSSSSSPAKSLNGSESSPPSQNHLENKVSG 280
                 |.|.....|.:|..||         |....|..:|.|| |..|:.||  |...::|..|.
Human   223 SPLKIHIPEPDLRSMVSPVPS---------PTGTISVPNSCPA-SPRGAGSS--SYRFVQNVTSD 275

  Fly   281 ---SAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQ 342
               :|......:|:|.|    ||:.....:...||..||..:|..||..:...:||||.|||::.
Human   276 LQLAAEFAAKAASEQQA----DTSGGDSPKDESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHIT 336

  Fly   343 KSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRRP 407
            |.|.::|....||:||:|||||||..|.|:|:..  .:||||::|.||..|.....::...:||.
Human   337 KHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQ--EEPGKGSFWRIDPASEAKLVEQAFRKRRQ 399

  Fly   408 RGYRSKIKVKPYAGHANGYYASGYGDAGMDNGNYYASPAFASYDYSAAGATGVSPAGG------- 465
            ||.              ..:.:.:|.  :.:.:..|||.....         :||..|
Human   400 RGV--------------SCFRTPFGP--LSSRSAPASPTHPGL---------MSPRSGGLQTPEC 439

  Fly   466 ---QGFADPWNAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGGNVNGS---ATTPPLAHSALG- 523
               :|...|   |....||....|       |:| ..|..|.|..|:..   ...||...|.:.
Human   440 LSREGSPIP---HDPEFGSKLASV-------PEY-RYSQSAPGSPVSAQPVIMAVPPRPSSLVAK 493

  Fly   524 ----MAPSASSSSSPLGAAATLQSDYAPTASLV-------------------AAGYSY-ATSAGS 564
                |..|..:|..|.|.|..:... |||.::|                   |||.|: |..|..
Human   494 PVAYMPASIVTSQQPAGHAIHVVQQ-APTVTMVRVVTTSANSANGYILTSQGAAGGSHDAAGAAV 557

  Fly   565 LDNGLRSISLQQLPGLS 581
            ||.|..:..|::.|.::
Human   558 LDLGSEARGLEEKPTIA 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	Forkhead	311..399	CDD:278670	39/87 (45%)
FOXK1	NP_001032242.1	Interaction with SIN3A and SIN3B. /evidence=ECO:0000250\|UniProtKB:P42128	2..40		4/10 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..79		12/43 (28%)
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000250\|UniProtKB:P42128	95..420		85/358 (24%)
		FHA	<102..204	CDD:224630	14/101 (14%)
		FHA	110..203	CDD:238017	12/92 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..306		5/22 (23%)
		Forkhead	305..391	CDD:278670	39/87 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..436		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810