DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bin and Foxh1

DIOPT Version :9

Sequence 1:	NP_523950.2	Gene:	bin / 38766	FlyBaseID:	FBgn0045759	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_032015.1	Gene:	Foxh1 / 14106	MGIID:	1347465	Length:	401	Species:	Mus musculus

Alignment Length:	351	Identity:	103/351 - (29%)
Similarity:	146/351 - (41%)	Gaps:	94/351 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 YSSSSSSPAKSLNGSESSPPSQNHLENKVSGSAVVGTGGSSQ---QDAPSTPDTTKKSGTR--RP 309
            |:.::.||..:|      .|:|.:|       ..:|...:||   .:|.|...|.|:...|  |.
Mouse    11 YTPTTPSPQLAL------APAQGYL-------PCMGPRDNSQLRPPEAESLSKTPKRRKKRYLRH 62

  Fly   310 EKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPK 374
            :||..:|:.||...|:.:|..:|.|::|...:|..:.|||..|.|||:|:|||||.|.||.|:||
Mouse    63 DKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFHKVPK 127

  Fly   375 GMGVGKP-GKGNYWTIDEN----SAHLFEDEGSLRR-RPRG-YRSKIK-VKPYAGHANGYYASGY 431
              ...|| .|||:|.:|.:    .|...::....|| :.|| :|:..| :.||..|
Mouse   128 --DPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVLH--------- 181

  Fly   432 GDAGMDNGNYYASPAFASYDYSAAGATGVSPAGGQGFA------DP-----WNAH--------AA 477
                   |..|..|:             ..|...:||:      ||     |..|        ||
Mouse   182 -------GQPYQPPS-------------PPPPPREGFSIKSLLGDPGKESTWPQHPGLPGQSTAA 226

  Fly   478 HSGSSSVG-VGMGVGP-------------LPQYTNISCLAAGGNV-NGSATTPPLAHSALG-MAP 526
            .:|:.|.| .|||.||             ||..|.|...::.|.| ..|..||......|. :..
Mouse   227 QAGTLSKGEEGMGTGPSSSSETPLWPLCSLPGPTIIEGESSQGEVIRPSPVTPDQGSWPLHLLED 291

  Fly   527 SASSSSSP-LGAAATLQSDYAPTASL 551
            ||.|...| .|:.|:|... .||:.|
Mouse   292 SADSRGVPRRGSRASLWGQ-LPTSYL 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	Forkhead	311..399	CDD:278670	38/92 (41%)
Foxh1	NP_032015.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57		7/24 (29%)
		FH	64..142	CDD:238016	36/79 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..251		21/100 (21%)
		SMAD-interaction domain (SID)	307..390		4/11 (36%)
		Fast/FoxH1 motif 1 (FM1)	311..315		2/3 (67%)
		Fast/FoxH1 motif 2 (FM2)	321..327
		SMAD interaction motif (SIM)	363..384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810