DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bin and FOXP4

DIOPT Version :9

Sequence 1:	NP_523950.2	Gene:	bin / 38766	FlyBaseID:	FBgn0045759	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_011512591.1	Gene:	FOXP4 / 116113	HGNCID:	20842	Length:	687	Species:	Homo sapiens

Alignment Length:	543	Identity:	127/543 - (23%)
Similarity:	200/543 - (36%)	Gaps:	168/543 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 MDATPTATPVSAAQHYSLSALHSMGTPPASSSPIP----PYG--VLMTAHSAGSASPQSNSKTPT 147
            :|.|.||...:           |...||..|.|:.    |.|  .::|:....|    |:.:||.
Human   257 LDLTGTAATAT-----------SFAAPPKVSPPLSHHTLPNGQPTVLTSRRDSS----SHEETPG 306

  Fly   148 DLP----------------QDL---------QYASSSTSTAK-------VQPLQVQLQPLNHQYA 180
            ..|                :||         ::|....|||:       ||.|::||..
Human   307 SHPLYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAK------ 365

  Fly   181 STIKYCSNNTILSANDYQLLTSQEQAGQQQPQQLPAQQLQHSPGGGYMSRISTSPSQVISNAHGM 245
                        .:...|.:.:.......:|:.. :|.|...||....|:::      :|.|...
Human   366 ------------ESERLQAMMAHLHMRPSEPKPF-SQPLNPVPGSSSFSKVT------VSAADSF 411

  Fly   246 P--VLNYSSSSSSPAKSLNGSESSPPSQNHLENKVSGSAVVGTGGSSQQ---DAPSTPDTTKKSG 305
            |  :::..:|:::|...|.     ||.        .|||.:..||.:::   |...:|.:::.:.
Human   412 PDGLVHPPTSAAAPVTPLR-----PPG--------LGSASLHGGGPARRRSSDKFCSPISSELAQ 463

  Fly   306 TRR-----PEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSL 365
            ...     ..:|..:|.::|..||.|:|..:|||:|||.:..:.:.:||.....|||:|||||||
Human   464 NHEFYKNADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSL 528

  Fly   366 NECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRRPRGYRSKIKVKPYAGHANGYYASG 430
            ::||.::       :..||..||:||.       |...||.|:...|...||      |......
Human   529 HKCFVRV-------ENVKGAVWTVDER-------EYQKRRPPKMTGSPTLVK------NMISGLS 573

  Fly   431 YGDAGMDNGNYYASPAFASYDYSAAGATGVSPAGGQGFADPWNAHA----AHSGSSSVGVGMGVG 491
            ||..   |.:|.|:.|.:|:..          ....|..:|.:|.:    :|.     .||..|.
Human   574 YGAL---NASYQAALAESSFPL----------LNSPGMLNPGSASSLLPLSHD-----DVGAPVE 620

  Fly   492 PLPQYTNISCLAAGGNVNGSATTPPLAHSALGMAPSASSSSSPLGAAATLQSDYAPTASLVAAGY 556
            |||.             |||::.|.|:      .|..|.........|..:.|..|...|.|...
Human   621 PLPS-------------NGSSSPPRLS------PPQYSHQVQVKEEPAEAEEDRQPGPPLGAPNP 666

  Fly   557 SYATSAGSLDNGLRSISLQQLPG 579
            |  .|....|..|.    ::|||
Human   667 S--ASGPPEDRDLE----EELPG 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	Forkhead	311..399	CDD:278670	33/87 (38%)
FOXP4	XP_011512591.1	FOXP-CC	310..377	CDD:292777	12/84 (14%)
FOXP4	XP_011512591.1	Forkhead	474..553	CDD:278670	34/92 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910