DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and GNA14

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_004288.1	Gene:	GNA14 / 9630	HGNCID:	4382	Length:	355	Species:	Homo sapiens

Alignment Length:	354	Identity:	178/354 - (50%)
Similarity:	237/354 - (66%)	Gaps:	3/354 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEE 66
            ||...:|.:||:...|..|:|.||.:.:.|..|:||||||.|||||||.:|||:|||.:|||.|:
Human     3 GCCCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 67

  Fly    67 CEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEIVLLMKKL 131
            .:.:.::|:.|...::..:||||..|:|::......:.| |...........:|..|.|..:|:|
Human    68 RKGFTKLVYQNIFTAMQAMIRAMDTLRIQYVCEQNKENA-QIIREVEVDKVSMLSREQVEAIKQL 131

  Fly   132 WADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQLH 196
            |.|.|:|:.:.|.|||||:|||.|||..:||||.|:::||||||||.||.||||||..|..:.:.
Human   132 WQDPGIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLENII 196

  Fly   197 FKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKWFV 261
            |::.|||||||||:|||||||.||:|||.||||.||.||||.:..|||.||..||.:|....||:
Human   197 FRMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFL 261

  Fly   262 ETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAA-NYIRMKFENLNKRKDQKEIYTHLT 325
            .:|:|||||||||.||||..|.|...||||||......|| ::|...:::.|..| :|.||:|.|
Human   262 NSSVILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVRAARDFILKLYQDQNPDK-EKVIYSHFT 325

  Fly   326 CATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            |||||:|::|||.||.|.|::.||::..|
Human   326 CATDTDNIRFVFAAVKDTILQLNLREFNL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	172/339 (51%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	163/314 (52%)
GNA14	NP_004288.1	G_alpha	16..353	CDD:214595	172/338 (51%)
		G-alpha	36..349	CDD:206639	163/314 (52%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	37..50		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		6/7 (86%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760