Protein Alignment Galphai and Gna12

DIOPT Version :10

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_112296.1
• Gene: Gna12 / 81663
• RGDID: 71018
• Length: 379
• Species: Rattus norvegicus
• Alignment Length: 367
• Identity: 149/367 - (40%)
• Similarity: 216/367 - (58%)
• Gaps: 35/367 - (9%)

  Fly     8 ARD--KEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEECEEY 70
            |||  :||..||::||..|..|.......||:||||||||||||.:|||:|||...:.|:...|:
  Rat    27 ARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEF 91

  Fly    71 RRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEI----------- 124
            |..:|.|.::...|::.|..:|.|.             :.|:.....|:.|...
  Rat    92 RDTIFDNILKGSRVLVDARDKLGIP-------------WQHSENEKHGMFLMAFENKAGLPVEPA 143

  Fly   125 -----VLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTG 184
                 |..:..||.|.|::::|:|..|:||.:|..|:|::||||.|.||.|::||:|..|..|.|
  Rat   144 TFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKG 208

  Fly   185 IIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLK 249
            |:|..|..|::.||:.|||||||:|:||..||:|:|:|:|.|:.|.||.||.||...||::||:.
  Rat   209 IVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMN 273

  Fly   250 LFDSICNSKWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTG-TNTFEEAANYIRMKFENLNK 313
            :|::|.|:|.|...||||||||.||..||:|...:...||::.| .:..|:...|:...|:  .|
  Rat   274 IFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFD--RK 336

  Fly   314 RKDQ-KEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            |::: |.::.|.|.|.||.|::|||.||.|.|::.|||.|.|
  Rat   337 RRNRGKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIML 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	133/331 (40%)
Gna12	NP_112296.1	G_alpha	40..377	CDD:214595	140/351 (40%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	57..70		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	198..206		3/7 (43%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	221..230		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	290..297		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	349..354		2/4 (50%)