DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and Gna12

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_112296.1	Gene:	Gna12 / 81663	RGDID:	71018	Length:	379	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	149/367 - (40%)
Similarity:	216/367 - (58%)	Gaps:	35/367 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ARD--KEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEECEEY 70
            |||  :||..||::||..|..|.......||:||||||||||||.:|||:|||...:.|:...|:
  Rat    27 ARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEF 91

  Fly    71 RRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEI----------- 124
            |..:|.|.::...|::.|..:|.|.             :.|:.....|:.|...
  Rat    92 RDTIFDNILKGSRVLVDARDKLGIP-------------WQHSENEKHGMFLMAFENKAGLPVEPA 143

  Fly   125 -----VLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTG 184
                 |..:..||.|.|::::|:|..|:||.:|..|:|::||||.|.||.|::||:|..|..|.|
  Rat   144 TFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKG 208

  Fly   185 IIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLK 249
            |:|..|..|::.||:.|||||||:|:||..||:|:|:|:|.|:.|.||.||.||...||::||:.
  Rat   209 IVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMN 273

  Fly   250 LFDSICNSKWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTG-TNTFEEAANYIRMKFENLNK 313
            :|::|.|:|.|...||||||||.||..||:|...:...||::.| .:..|:...|:...|:  .|
  Rat   274 IFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFD--RK 336

  Fly   314 RKDQ-KEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            |::: |.::.|.|.|.||.|::|||.||.|.|::.|||.|.|
  Rat   337 RRNRGKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIML 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	142/356 (40%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	133/331 (40%)
Gna12	NP_112296.1	G_alpha	40..377	CDD:214595	140/351 (40%)
		G-alpha	56..373	CDD:206639	133/331 (40%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	57..70		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	198..206		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	221..230		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	290..297		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	349..354		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.760