DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and Gnao1

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_059023.1	Gene:	Gnao1 / 50664	RGDID:	628732	Length:	354	Species:	Rattus norvegicus

Alignment Length:	363	Identity:	231/363 - (63%)
Similarity:	283/363 - (77%)	Gaps:	17/363 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||.:| |.::.|:||||.|::.|:.:|..||.:||||||||||||||||||||||||:.|:|.|
  Rat     1 MGCTLS-AEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGE 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTD--------IARQFFTHASAADEGILLP 122
            :.::|:.||:|||:|||..|:|||..|.:|:.|..|..        ::|...|...:|
  Rat    65 DVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKADSKMVCDVVSRMEDTEPFSA------- 122

  Fly   123 EIVLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIE 187
            |::..|.:||.|.|:|:.|.|||||||||||.|||:|||||...:|.||:||:||||||||||:|
  Rat   123 ELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVE 187

  Fly   188 THFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFD 252
            |||:.|.|||:|||||||||||||||||||.||||||||||||||.||.|||..|||.|||.|||
  Rat   188 THFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFD 252

  Fly   253 SICNSKWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQ 317
            ||||:|:|::|||||||||||||.||||:||||||||||.|:||:|:||.||:.:||:.| |...
  Rat   253 SICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKN-RSPN 316

  Fly   318 KEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGLF 355
            ||||.|:||||||||::.|||||||:||.|||:..||:
  Rat   317 KEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	223/346 (64%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	212/321 (66%)
Gnao1	NP_059023.1	G-alpha	34..348	CDD:206639	212/321 (66%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		6/7 (86%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730