DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and gna12a

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001013295.1	Gene:	gna12a / 503589	ZFINID:	ZDB-GENE-050221-1	Length:	385	Species:	Danio rerio

Alignment Length:	352	Identity:	145/352 - (41%)
Similarity:	217/352 - (61%)	Gaps:	9/352 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEECEEYRRV 73
            |::||..||:.||..|:.|.......||:||||||||||||.:|||:|||...:.|:...::|..
Zfish    36 REREAKRRSREIDSMLKRERRSIRRLVKILLLGAGESGKSTFLKQMRIIHGKEFDQKALLDFRDT 100

  Fly    74 VFSNTVQSLMVIIRAMGRLKIEFADPSRTD---IARQFFTHASAADEGILLPEIVLLMKKLWADG 135
            :|.|.::.:.|::.|..:|.|.:.:.....   ....|...|..|.|.......|..::.||.|.
Zfish   101 IFENVIKGMRVLVDARDKLGISWQNSENEKHGMFVMSFENKAGMAVEPCTFQLYVPALQALWNDS 165

  Fly   136 GVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQLHFKLF 200
            |:|:::.|..|:||::|..|:|::||||.|.:|:|::||:|..|..|.||:|..|..|::.||:.
Zfish   166 GIQEAYGRRSEFQLSESVKYFLDNLDRIGQLSYVPSRQDILLARKATKGIVEHDFVIKKIPFKMV 230

  Fly   201 DVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKWFVETSI 265
            |||||||:|:||..||:|:|:|:|.|:.|.||.||.||...||::||:.:|::|.|:|.|...||
Zfish   231 DVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFSNVSI 295

  Fly   266 ILFLNKKDLFEEKIKRSPLTIC--FPEYTG-TNTFEEAANYIRMKFENLNKRKDQKEIYTHLTCA 327
            ||||||.||..||:::  ::||  |.::.| .:...:...|:...| |..:|...|.::.|.|.|
Zfish   296 ILFLNKMDLLVEKVRK--VSICKHFSDFRGDPHRLVDVQAYLVQCF-NRKRRNRIKPLFHHFTTA 357

  Fly   328 TDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            .||.|::|||.||.|.|::.|||.|.|
Zfish   358 IDTENIRFVFHAVKDTILQENLKDIML 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	140/344 (41%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	131/319 (41%)
gna12a	NP_001013295.1	G_alpha	41..383	CDD:214595	140/344 (41%)
gna12a	NP_001013295.1	G-alpha	62..379	CDD:206639	131/319 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760