DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and gna11

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_989150.1	Gene:	gna11 / 394755	XenbaseID:	XB-GENE-944497	Length:	359	Species:	Xenopus tropicalis

Alignment Length:	364	Identity:	174/364 - (47%)
Similarity:	232/364 - (63%)	Gaps:	22/364 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSK----NIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTG 61
            |.|.:|     |.::.||    .|::.||.:.:.:..|:||||||.|||||||.:|||:|||.:|
Frog     7 MACCLS-----EEVKESKRINAEIEKQLRRDKKDSRRELKLLLLGTGESGKSTFIKQMRIIHGSG 66

  Fly    62 YSQEECEEYRRVVFSNTVQSLMVIIRAMGRLKIEF---ADPSRTDIARQFFTHASAADEGILLPE 123
            ||:|:...:.::||.|...::..:||||..|||.:   .:.:...:.|:.........|    ..
Frog    67 YSEEDKRGFTKLVFQNIFTAMQSMIRAMDTLKIPYKCEQNKANAQVVREVDVEKVCTFE----QP 127

  Fly   124 IVLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIET 188
            .|..:|.||:|.|:|:.:.|.|||||:|||.|||..:|||::|.|:||||||||.||.||||||.
Frog   128 YVNAIKNLWSDPGIQECYDRRREYQLSDSAKYYLTDVDRISKPGYLPTQQDVLRVRVPTTGIIEY 192

  Fly   189 HFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDS 253
            .|..:.:.|::.|||||||||:|||||||.||:|:|.||||.||.||.|.:..|||.||..||.:
Frog   193 PFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRT 257

  Fly   254 ICNSKWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAA---NYIRMKFENLNKRK 315
            |....||..:|:|||||||||.|:||..|.|...|||:.|..  .:||   .:|...|.:||...
Frog   258 IITYPWFQNSSVILFLNKKDLLEDKIMYSHLVDYFPEFDGPQ--RDAATAREFILKMFVDLNPDS 320

  Fly   316 DQKEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            | |.||:|.||||||.|::|||.||.|.|:::|||:..|
Frog   321 D-KIIYSHFTCATDTENIRFVFAAVKDTILQHNLKEYNL 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	169/348 (49%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	160/319 (50%)
gna11	NP_989150.1	G-alpha	40..353	CDD:206639	160/319 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010