DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Galphai and gnai1

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_957265.1	Gene:	gnai1 / 393946	ZFINID:	ZDB-GENE-040426-1310	Length:	354	Species:	Danio rerio

Alignment Length:	355	Identity:	271/355 - (76%)
Similarity:	310/355 - (87%)	Gaps:	1/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||.:|| .||.|:||||.|||.||.:||:||.|||||||||||||||||||||||||:.|||:|
Zfish     1 MGCTLST-EDKAAVERSKMIDRNLRDDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEE 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEIVLLMKK 130
            ||::|:.||:|||:||::.||||||||||:|.|.:|.|.|||.|..|.:|:||.:..|:..::|:
Zfish    65 ECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDAARADDARQLFVLAGSAEEGFMTAELAGVIKR 129

  Fly   131 LWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQL 195
            ||.|||||..|:|||||||||||.||||.||||:|..||||||||||||||||||:||||:.|.|
Zfish   130 LWKDGGVQACFSRSREYQLNDSAAYYLNDLDRISQATYIPTQQDVLRTRVKTTGIVETHFTFKDL 194

  Fly   196 HFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKWF 260
            |||:||||||||||||||||||||||||||||||.||||||||||||||.||:||||||||:|||
Zfish   195 HFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWF 259

  Fly   261 VETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQKEIYTHLT 325
            .:|||||||||||||||||::|.||||:|||.|:||:||||.||:.:||:||||||.||||||.|
Zfish   260 TDTSIILFLNKKDLFEEKIRKSTLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFT 324

  Fly   326 CATDTNNVKFVFDAVTDVIIKNNLKQIGLF 355
            |||||.||:||||||||||||||||..|||
Zfish   325 CATDTKNVQFVFDAVTDVIIKNNLKDCGLF 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	260/338 (77%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	243/313 (78%)
gnai1	NP_957265.1	G_alpha	14..352	CDD:214595	260/337 (77%)
gnai1	NP_957265.1	G-alpha	34..348	CDD:206639	243/313 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	522	1.000	Domainoid score	I284
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74417
Inparanoid	1	1.050	554	1.000	Inparanoid score	I1088
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	1	1.000	-	-		otm25232
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	1	1.100	-	-	LDO	PTHR10218
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870