DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and GNAT3

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001095856.1	Gene:	GNAT3 / 346562	HGNCID:	22800	Length:	354	Species:	Homo sapiens

Alignment Length:	355	Identity:	220/355 - (61%)
Similarity:	280/355 - (78%)	Gaps:	1/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            ||..:| :..||:.:|||.:::.|:.:.||.|..||||||||||||||||||||||||..|||::
Human     1 MGSGIS-SESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSEQ 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEIVLLMKK 130
            ||.|::.|::|||:||::.|::||..|.|::.:|...:..||.:..|:..::|.:.|::..::|:
Human    65 ECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMTPQLAEVIKR 129

  Fly   131 LWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQL 195
            ||.|.|:|..|.|:.||||||||.||||.||||....|:|.:||||.:||||||||||.||.|.|
Human   130 LWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVKTTGIIETQFSFKDL 194

  Fly   196 HFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKWF 260
            ||::|||||||||||||||||||||.||||.|||.||:||.||||:|||.|||.||:||||.|:|
Human   195 HFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYF 259

  Fly   261 VETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQKEIYTHLT 325
            ..|||:|||||||:|:||:.:..|:||||||||.||||:|.|||:.:|.:||.:|:.||||:|:|
Human   260 STTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAGNYIKNQFLDLNLKKEDKEIYSHMT 324

  Fly   326 CATDTNNVKFVFDAVTDVIIKNNLKQIGLF 355
            |||||.|||||||||||:|||.|||..|||
Human   325 CATDTQNVKFVFDAVTDIIIKENLKDCGLF 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	212/338 (63%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	202/313 (65%)
GNAT3	NP_001095856.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		9/26 (35%)
		G-alpha	34..348	CDD:206639	202/313 (65%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	1	1.100	-	-	O	PTHR10218
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.720