Protein Alignment Galphai and GNAS

DIOPT Version :9

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: XP_016883301.1
• Gene: GNAS / 2778
• HGNCID: 4392
• Length: 1038
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 157/404 - (38%)
• Similarity: 216/404 - (53%)
• Gaps: 76/404 - (18%)

  Fly    11 KEAIE----------RSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||:|          |||.||:.|:.|........:||||||||||||||||||:|:|..|::.|
Human   650 KEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGE 714

  Fly    66 ECEEYRRVVFSNT----------------VQSLMVIIRAMGRL--KIEFADPSRT---------- 102
            ..||..:...||:                .:::..|:.||..|  .:|.|:|...
Human   715 GGEEDPQAARSNSDGSEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVM 779

  Fly   103 -----DIARQFFTHASAADEGILLPEIVLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDR 162
                 |...:|:.||                |.||.|.||:..:.||.||||.|.|.|:|:.:|.
Human   780 NVPDFDFPPEFYEHA----------------KALWEDEGVRACYERSNEYQLIDCAQYFLDKIDV 828

  Fly   163 IAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVA 227
            |.|.:|:|:.||:||.||.|:||.||.|...:::|.:|||||||.||:|||.||..||||||.||
Human   829 IKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVA 893

  Fly   228 LSGYDLVLAEDEEMNRMIESLKLFDSICNSKWFVETSIILFLNKKDLFEEKI--KRSPLTICFPE 290
            .|.|::|:.||.:.||:.|:|.||.||.|::|....|:||||||:||..||:  .:|.:...|||
Human   894 SSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPE 958

  Fly   291 YTGTNTFEEA------------ANY-IRMKFENLNKRK--DQKEIYTHLTCATDTNNVKFVFDAV 340
            :....|.|:|            |.| ||.:|..::...  .:...|.|.|||.||.|::.||:..
Human   959 FARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDC 1023

  Fly   341 TDVIIKNNLKQIGL 354
            .|:|.:.:|:|..|
Human  1024 RDIIQRMHLRQYEL 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	153/398 (38%)
		G-alpha	35..349	CDD:206639	143/363 (39%)
GNAS	XP_016883301.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750