Protein Alignment Galphai and GNAO1

DIOPT Version :10

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_066268.1
• Gene: GNAO1 / 2775
• HGNCID: 4389
• Length: 354
• Species: Homo sapiens
• Alignment Length: 356
• Identity: 233/356 - (65%)
• Similarity: 281/356 - (78%)
• Gaps: 3/356 - (0%)

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||.:| |.::.|:||||.|::.|:.:|..||.:||||||||||||||||||||||||:.|:|.|
Human     1 MGCTLS-AEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGE 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHAS-AADEGILLPEIVLLMK 129
            :.::|:.||:|||:|||..|:|||..|.||:.|..|...|:......| ..|......|::..|.
Human    65 DVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMM 129

  Fly   130 KLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQ 194
            :||.|.|:|:.|.|||||||||||.|||:|||||...:|.||:||:||||||||||:||||:.|.
Human   130 RLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKN 194

  Fly   195 LHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKW 259
            |||:|||||||||||||||||||.||||||||||||||.||.|||..|||.|||.|||||||:|:
Human   195 LHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKF 259

  Fly   260 FVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQKEIYTHL 324
            |::|||||||||||||.||||:||||||||||||.||:|:||.||:.:||:.| |...||||.|:
Human   260 FIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKN-RSPNKEIYCHM 323

  Fly   325 TCATDTNNVKFVFDAVTDVIIKNNLKQIGLF 355
            ||||||||::.|||||||:||.|||:..||:
Human   324 TCATDTNNIQVVFDAVTDIIIANNLRGCGLY 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	214/314 (68%)
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	214/314 (68%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		6/7 (86%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)