Protein Alignment Galphai and GNAI2

DIOPT Version :9

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_002061.1
• Gene: GNAI2 / 2771
• HGNCID: 4385
• Length: 355
• Species: Homo sapiens
• Alignment Length: 356
• Identity: 272/356 - (76%)
• Similarity: 308/356 - (86%)
• Gaps: 2/356 - (0%)

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||.|| |.||.|.||||.||:.||.:||:||.|||||||||||||||||||||||||:.|||:|
Human     1 MGCTVS-AEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEE 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADE-GILLPEIVLLMK 129
            ||.:||.||:|||:||:|.|::|||.|:|:||||||.|.|||.|..:..|:| |:|..::..:::
Human    65 ECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIR 129

  Fly   130 KLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQ 194
            :||||.|||..|.|||||||||||.||||.|:||||.:||||||||||||||||||:||||:.|.
Human   130 RLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKD 194

  Fly   195 LHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKW 259
            ||||:||||||||||||||||||||||||||||||.||||||||||||||.||:||||||||:||
Human   195 LHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKW 259

  Fly   260 FVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQKEIYTHL 324
            |.:|||||||||||||||||..||||||||||||.|.::|||:||:.|||:||||||.||||||.
Human   260 FTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHF 324

  Fly   325 TCATDTNNVKFVFDAVTDVIIKNNLKQIGLF 355
            ||||||.||:||||||||||||||||..|||
Human   325 TCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	260/339 (77%)
		G-alpha	35..349	CDD:206639	244/314 (78%)
GNAI2	NP_002061.1	G-alpha	34..349	CDD:206639	244/314 (78%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		7/7 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	325..330		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	530	1.000	Domainoid score	I281
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	563	1.000	Inparanoid score	I1086
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	1	1.000	-	-		otm42046
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770