Protein Alignment Galphai and GNA15

DIOPT Version :10

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_002059.3
• Gene: GNA15 / 2769
• HGNCID: 4383
• Length: 374
• Species: Homo sapiens
• Alignment Length: 371
• Identity: 160/371 - (43%)
• Similarity: 214/371 - (57%)
• Gaps: 35/371 - (9%)

  Fly     7 TARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEECEEYR 71
            |..:|.|....:.|:|.|..:.::...|:||||||.|||||||.:|||:|||..|||:||.:.:|
Human    15 TEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEERKGFR 79

  Fly    72 RVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHAS---AADEGILLPEIVLLMKK--- 130
            .:|:.|...|:..:|.||.||:|.|:.|....       |||   :.|     |..|...:|
Human    80 PLVYQNIFVSMRAMIEAMERLQIPFSRPESKH-------HASLVMSQD-----PYKVTTFEKRYA 132

  Fly   131 -----LWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHF 190
                 ||.|.|::..:.|.||:.|.|||.|||:.|:||.:..|:||.|||||:|:.||||.|..|
Human   133 AAMQWLWRDAGIRACYERRREFHLLDSAVYYLSHLERITEEGYVPTAQDVLRSRMPTTGINEYCF 197

  Fly   191 SCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSIC 255
            |.::.:.::.|||||:|||||||||||.|.|:|:..:||.||..|.|:.:.|||.|||.||.:|.
Human   198 SVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTIL 262

  Fly   256 NSKWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAAN------YIRMKF------ 308
            ...||..||:||||||.|:.||||..|.|...||.:.|.....|||.      |.||..
Human   263 ELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFQGPKQDAEAAKRFILDMYTRMYTGCVDGP 327

  Fly   309 ENLNKRKDQKEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            |...|....:.:::|.||||||.|::.||..|.|.::...|.:|.|
Human   328 EGSKKGARSRRLFSHYTCATDTQNIRKVFKDVRDSVLARYLDEINL 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	150/336 (45%)
GNA15	NP_002059.3	G_alpha	22..372	CDD:214595	155/361 (43%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	44..57		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	181..189		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	204..213		4/8 (50%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	273..280		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	344..349		4/4 (100%)