Protein Alignment Galphai and GNA12

DIOPT Version :9

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_031379.2
• Gene: GNA12 / 2768
• HGNCID: 4380
• Length: 381
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 151/357 - (42%)
• Similarity: 219/357 - (61%)
• Gaps: 7/357 - (1%)

  Fly     4 AVSTARD--KEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEE 66
            |.|.|||  :||..||::||..|..|.......||:||||||||||||.:|||:|||...:.|:.
Human    25 AGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKA 89

  Fly    67 CEEYRRVVFSNTVQSLMVIIRAMGRLKI--EFADPSRTDIARQFFTH-ASAADEGILLPEIVLLM 128
            ..|:|..:|.|.::...|::.|..:|.|  ::::..:..:....|.: |....|.......|..:
Human    90 LLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPAL 154

  Fly   129 KKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCK 193
            ..||.|.|::::|:|..|:||.:|..|:|::||||.|.||.|::||:|..|..|.||:|..|..|
Human   155 SALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIK 219

  Fly   194 QLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSK 258
            ::.||:.|||||||:|:||..||:|:|:|:|.|:.|.||.||.||...||::||:.:|::|.|:|
Human   220 KIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNK 284

  Fly   259 WFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTG-TNTFEEAANYIRMKFENLNKRKDQKEIYT 322
            .|...||||||||.||..||:|...:...||::.| .:..|:...|:...|:. .:|...|.::.
Human   285 LFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDR-KRRNRSKPLFH 348

  Fly   323 HLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            |.|.|.||.||:|||.||.|.|::.|||.|.|
Human   349 HFTTAIDTENVRFVFHAVKDTILQENLKDIML 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	142/342 (42%)
		G-alpha	35..349	CDD:206639	133/317 (42%)
GNA12	NP_031379.2	G_alpha	42..379	CDD:214595	140/337 (42%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	59..72		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	200..208		3/7 (43%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	223..232		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	292..299		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	351..356		2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.760