DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and Gnas

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_038960221.1	Gene:	Gnas / 24896	RGDID:	2716	Length:	1145	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	157/404 - (38%)
Similarity:	215/404 - (53%)	Gaps:	76/404 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KEAIE----------RSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||:|          |||.||:.|..|........:||||||||||||||||||:|:|..|::.|
  Rat   757 KEAMEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGE 821

  Fly    66 ECEEYRRVVFSNT----------------VQSLMVIIRAMGRL--KIEFADPSRT---------- 102
            ..||..:...||:                .:::..|:.||..|  .:|.|:|...
  Rat   822 GGEEDPQAARSNSDGSEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVM 886

  Fly   103 -----DIARQFFTHASAADEGILLPEIVLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDR 162
                 |...:|:.||                |.||.|.||:..:.||.||||.|.|.|:|:.:|.
  Rat   887 NVPNFDFPPEFYEHA----------------KALWEDEGVRACYERSNEYQLIDCAQYFLDKIDV 935

  Fly   163 IAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVA 227
            |.|.:|:|:.||:||.||.|:||.||.|...:::|.:|||||||.||:|||.||..||||||.||
  Rat   936 IKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVA 1000

  Fly   228 LSGYDLVLAEDEEMNRMIESLKLFDSICNSKWFVETSIILFLNKKDLFEEKI--KRSPLTICFPE 290
            .|.|::|:.||.:.||:.|:|.||.||.|::|....|:||||||:||..||:  .:|.:...|||
  Rat  1001 SSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPE 1065

  Fly   291 YTGTNTFEEA------------ANY-IRMKFENLNKRK--DQKEIYTHLTCATDTNNVKFVFDAV 340
            :....|.|:|            |.| ||.:|..::...  .:...|.|.|||.||.|::.||:..
  Rat  1066 FARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDC 1130

  Fly   341 TDVIIKNNLKQIGL 354
            .|:|.:.:|:|..|
  Rat  1131 RDIIQRMHLRQYEL 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	153/398 (38%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	143/363 (39%)
Gnas	XP_038960221.1	PHA03247	<122..560	CDD:223021
		UDM1_RNF168_RNF169-like	741..>783	CDD:409016	10/25 (40%)
		G-alpha	791..1139	CDD:206639	143/363 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920