DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and gpa-3

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001309498.1	Gene:	gpa-3 / 179319	WormBaseID:	WBGene00001665	Length:	353	Species:	Caenorhabditis elegans

Alignment Length:	355	Identity:	181/355 - (50%)
Similarity:	244/355 - (68%)	Gaps:	3/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            ||...| |.|||...:||.||:.:..........||||||||||.||||::|||:|:||.|::.|
Worm     1 MGLCQS-AEDKELTLKSKAIDKEMMQNHMSQQKVVKLLLLGAGECGKSTVLKQMRILHDHGFTAE 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLP-EIVLLMK 129
            |.|:.:.|||:||:|::..|::.|..|::.|..|.|.:.|:..........|..:.| |:...::
Worm    65 EAEQQKSVVFNNTLQAMTAILKGMEALRMTFDKPIRENDAKFVMESHKMLQEAKVFPEELANAIQ 129

  Fly   130 KLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQ 194
            .||.|..|||..|:..|:|:.:||.::|:|||||..|:|.||:||:|.:|:|||||:|..|..|.
Worm   130 ALWNDKAVQQVIAKGNEFQMPESAPHFLSSLDRIKLPDYNPTEQDILLSRIKTTGIVEVKFQMKS 194

  Fly   195 LHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKW 259
            :.|::||||||||||||||||||.|.||||..|:|.||.||.|||..||||||::||:|||||:|
Worm   195 VDFRVFDVGGQRSERKKWIHCFEDVNAIIFIAAISEYDQVLFEDETTNRMIESMRLFESICNSRW 259

  Fly   260 FVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQKEIYTHL 324
            |:.||:||||||||||.|||||:.:...||:|.|..|::|:..||..||:.|| ...:|.||.|.
Worm   260 FINTSMILFLNKKDLFAEKIKRTSIKSAFPDYKGAQTYDESCRYIEEKFDGLN-ANPEKTIYMHQ 323

  Fly   325 TCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            ||||||:.|:.:.|:|.|:||:.||:..||
Worm   324 TCATDTDQVQMILDSVIDMIIQANLQGCGL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	172/339 (51%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	166/314 (53%)
gpa-3	NP_001309498.1	G-alpha	34..348	CDD:206639	166/314 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730