DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and gpa-2

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_505157.1	Gene:	gpa-2 / 179219	WormBaseID:	WBGene00001664	Length:	356	Species:	Caenorhabditis elegans

Alignment Length:	369	Identity:	163/369 - (44%)
Similarity:	223/369 - (60%)	Gaps:	37/369 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            :|...|.|.|||.        :.|:...||.   ||||||||||.||||::|||:::....|:.|
Worm    11 VGTLKSRAIDKEI--------KQLQTSEERT---VKLLLLGAGECGKSTVLKQMRLLTSKQYTDE 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSR-----------TDIARQFFTHASAADEGI 119
            |.....::|::|.|..:..:::||....:.|:||.|           .|:..:.| ...|||.
Worm    65 ELLTQAKLVYTNIVIEMDHLVKAMPAAGLNFSDPMREHDVHMLTLYIKDMQHKNF-QQDAADH-- 126

  Fly   120 LLPEIVLLMKKLWADGGVQQSFARSREY---QLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVK 181
                    ::|||.|..|::.:|..:|.   .:.|:..|:..:|.||::.:|.|...|.|..|.|
Worm   127 --------VEKLWKDPVVKRLYAERKELNIRDIGDNTEYFFENLPRISKEDYHPNATDTLLLRTK 183

  Fly   182 TTGIIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIE 246
            ||||:|..|..|::.|::||||||||||||||||||.|.||||..|||.|:.||.|||..|||||
Worm   184 TTGIVEVGFEIKKVKFRVFDVGGQRSERKKWIHCFEDVNAIIFIAALSEYNEVLFEDETTNRMIE 248

  Fly   247 SLKLFDSICNSKWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENL 311
            |::||:|||||:||..|:||||||||||||||||:..:...||||.|...:.|...:|:.|||.|
Worm   249 SMRLFESICNSRWFHNTNIILFLNKKDLFEEKIKKENIHKAFPEYRGEQNYAETVAFIKTKFEAL 313

  Fly   312 NKRKDQKEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGLF 355
            : ...:|..|.|.|||||||.|:.:.|:|..:||::||.:.||:
Worm   314 S-NNPKKTFYVHETCATDTNQVQKILDSVISMIIQSNLHKSGLY 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	155/352 (44%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	150/327 (46%)
gpa-2	NP_505157.1	G_alpha	13..354	CDD:214595	160/363 (44%)
gpa-2	NP_505157.1	G-alpha	34..350	CDD:206639	150/327 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730