DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and gpa-16

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_490790.1	Gene:	gpa-16 / 171675	WormBaseID:	WBGene00001678	Length:	357	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	228/358 - (63%)
Similarity:	277/358 - (77%)	Gaps:	4/358 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||.:| ..|:.|..|||.|||.|:.:||.:...:|||||||||||||||:|||:||||.||:.|
Worm     1 MGCIMS-QEDEAAKRRSKKIDRLLKEDGENSMRTIKLLLLGAGESGKSTILKQMRIIHDVGYTTE 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEIVLLMKK 130
            |.:.:|.||:.|.:.||..||.||.:|||.|........||:....::..:|..|..|:|:|||.
Worm    65 ERKVFRGVVYGNIILSLNAIIHAMEQLKISFTTLDHESDARKLLMFSTTGEEDELPEELVVLMKS 129

  Fly   131 LWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQL 195
            :|:|.|:|::..|||||||||||||||:.||||..|||||||.|:||||:|||||:||.|..|..
Worm   130 VWSDSGIQKALERSREYQLNDSAGYYLSQLDRICAPNYIPTQDDILRTRIKTTGIVETQFVYKDR 194

  Fly   196 HFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKWF 260
            .|.:||||||||||||||||||.|||:|||||||.||:||.||.:.|||.|||||||||||:|||
Worm   195 LFLVFDVGGQRSERKKWIHCFEDVTALIFCVALSEYDMVLVEDCQTNRMRESLKLFDSICNNKWF 259

  Fly   261 VETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKR---KDQKEIYT 322
            |||||||||||||||||||.|||||.|||||||.|.:|||:.||:.:||::|||   :..:||||
Worm   260 VETSIILFLNKKDLFEEKIVRSPLTHCFPEYTGANNYEEASAYIQQQFEDMNKRTTGEKNQEIYT 324

  Fly   323 HLTCATDTNNVKFVFDAVTDVIIKNNLKQIGLF 355
            ..||||||||::||||||||:||::||:..||:
Worm   325 QFTCATDTNNIRFVFDAVTDIIIRDNLRTCGLY 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	220/341 (65%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	209/316 (66%)
gpa-16	NP_490790.1	G_alpha	13..355	CDD:214595	220/341 (65%)
gpa-16	NP_490790.1	G-alpha	34..351	CDD:206639	209/316 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159560
Domainoid	1	1.000	436	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74417
Inparanoid	1	1.050	456	1.000	Inparanoid score	I890
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	1	1.000	-	-		oto20501
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	1	1.100	-	-	LDO	PTHR10218
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840