DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and Gnaz

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001345777.1	Gene:	Gnaz / 14687	MGIID:	95780	Length:	355	Species:	Mus musculus

Alignment Length:	355	Identity:	218/355 - (61%)
Similarity:	273/355 - (76%)	Gaps:	2/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||..| :.:|||..||:.|||.||:|.:|...|:||||||...||||||||||||||..|::.:
Mouse     1 MGCRQS-SEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNSGKSTIVKQMKIIHSGGFNLD 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAAD-EGILLPEIVLLMK 129
            .|:||:.::..|.:.||..||||:..|||:|.:|.|...|.|.|.....|: :|.:.||::.:|:
Mouse    65 ACKEYKPLIIYNAIDSLTRIIRALAALKIDFHNPDRAYDAVQLFALTGPAESKGEITPELLGVMR 129

  Fly   130 KLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQ 194
            :||||.|.|..|.||.||.|.|:|.||||.|:|||.|:||||.:|:||:|..||||:|..|:.|:
Mouse   130 RLWADPGAQACFGRSSEYHLEDNAAYYLNDLERIAAPDYIPTVEDILRSRDMTTGIVENKFTFKE 194

  Fly   195 LHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKW 259
            |.||:.||||||||||||||||||||||||||.||||||.|.||.:.:||.|||:|||||||:.|
Mouse   195 LTFKMVDVGGQRSERKKWIHCFEGVTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNW 259

  Fly   260 FVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQKEIYTHL 324
            |:.||:|||||||||..|||:|.||::|||||.|.||:||||.||:.:||:||:.|:.||||:|.
Mouse   260 FINTSLILFLNKKDLLAEKIRRIPLSVCFPEYKGQNTYEEAAVYIQRQFEDLNRNKETKEIYSHF 324

  Fly   325 TCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            ||||||:|::|||||||||||:||||.|||
Mouse   325 TCATDTSNIQFVFDAVTDVIIQNNLKYIGL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	208/339 (61%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	195/314 (62%)
Gnaz	NP_001345777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		14/25 (56%)
		G-alpha	34..349	CDD:206639	195/314 (62%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		9/12 (75%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830