DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and Gnaq

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_032165.3	Gene:	Gnaq / 14682	MGIID:	95776	Length:	359	Species:	Mus musculus

Alignment Length:	358	Identity:	179/358 - (50%)
Similarity:	229/358 - (63%)	Gaps:	10/358 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |.|.:| ...|||...:..|:|.||.:...|..|:||||||.|||||||.:|||:|||.:|||.|
Mouse     7 MACCLS-EEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDE 70

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFA---DPSRTDIARQFFTHASAADEGILLPEIVLL 127
            :...:.::|:.|...::..:||||..|||.:.   :.:...:.|:......:|.|...:..|
Mouse    71 DKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAI--- 132

  Fly   128 MKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSC 192
             |.||.|.|:|:.:.|.|||||:||..||||.|||:|.|:|:||||||||.||.||||||..|..
Mouse   133 -KSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDL 196

  Fly   193 KQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNS 257
            :.:.|::.|||||||||:|||||||.||:|:|.||||.||.||.|.:..|||.||..||.:|...
Mouse   197 QSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITY 261

  Fly   258 KWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAA-NYIRMKFENLNKRKDQKEIY 321
            .||..:|:|||||||||.||||..|.|...||||.|.....:|| .:|...|.:||...| |.||
Mouse   262 PWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSD-KIIY 325

  Fly   322 THLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            :|.||||||.|::|||.||.|.|::.|||:..|
Mouse   326 SHFTCATDTENIRFVFAAVKDTILQLNLKEYNL 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	172/342 (50%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	163/317 (51%)
Gnaq	NP_032165.3	G-alpha	40..353	CDD:206639	163/317 (51%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	41..54		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	178..186		6/7 (86%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	201..210		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	329..334		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830