DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and Gna11

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_034431.1	Gene:	Gna11 / 14672	MGIID:	95766	Length:	359	Species:	Mus musculus

Alignment Length:	367	Identity:	172/367 - (46%)
Similarity:	226/367 - (61%)	Gaps:	28/367 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |.|.:|. ..||:...:..|::.||.:...|..|:||||||.|||||||.:|||:|||..|||:|
Mouse     7 MACCLSD-EVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEE 70

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEI------ 124
            :...:.::|:.|...::..::|||..|||             .:.:.......:|:.|:
Mouse    71 DKRGFTKLVYQNIFTAMQAMVRAMETLKI-------------LYKYEQNKANALLIREVDVEKVT 122

  Fly   125 ------VLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTT 183
                  |..:|.||:|.|||:.:.|.||:||:|||.|||..:||||...|:||||||||.||.||
Mouse   123 TFEHQYVNAIKTLWSDPGVQECYDRRREFQLSDSAKYYLTDVDRIATVGYLPTQQDVLRVRVPTT 187

  Fly   184 GIIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESL 248
            ||||..|..:.:.|::.|||||||||:|||||||.||:|:|.||||.||.||.|.:..|||.||.
Mouse   188 GIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESK 252

  Fly   249 KLFDSICNSKWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAA-NYIRMKFENLN 312
            .||.:|....||..:|:|||||||||.|:||..|.|...|||:.|.....:|| .:|...|.:||
Mouse   253 ALFRTIITYPWFQNSSVILFLNKKDLLEDKILHSHLVDYFPEFDGPQRDAQAAREFILKMFVDLN 317

  Fly   313 KRKDQKEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            ...| |.||:|.||||||.|::|||.||.|.|::.|||:..|
Mouse   318 PDSD-KIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNL 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	166/351 (47%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	158/326 (48%)
Gna11	NP_034431.1	G-alpha	40..353	CDD:206639	158/326 (48%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	41..54		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	178..186		6/7 (86%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	201..210		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	329..334		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830