DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphai and mcoln2

DIOPT Version :9

Sequence 1:	NP_477502.1	Gene:	Galphai / 38765	FlyBaseID:	FBgn0001104	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_002931739.3	Gene:	mcoln2 / 100379826	XenbaseID:	XB-GENE-5767908	Length:	555	Species:	Xenopus tropicalis

Alignment Length:	276	Identity:	57/276 - (20%)
Similarity:	96/276 - (34%)	Gaps:	64/276 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ERAASEVKLLLL----GAGESGKSTIVKQMKIIHDTGYSQEECEEYRRVVFSNTVQSLMVIIRAM 89
            |.:....|.|.|    |..|...|..|...|.::|:.:.  ..|:|||         |..|  ::
Frog    82 EESTMAFKHLFLKGYTGRDEDDCSRTVYTQKDVYDSIFF--AIEQYRR---------LKEI--SL 133

  Fly    90 GRLKIEFADPSRTDIARQ-------------FFTHASAADEGILLPEIVLLMKKLWADGGVQQSF 141
            |.:..|..:.....:.:|             |:...:...|.:.|...||..|:......:..:|
Frog   134 GTVAYERGEKRGLKVCKQHYHQDSIHPSNDTFYIDPNVETECLHLQHEVLASKQPPNMSAINSTF 198

  Fly   142 ARSREYQL-NDSAGYYLNSLD----RIAQ-PNYIPTQQDVLRTRVKTTGIIETHF-------SCK 193
            .....|:| .....:.|..:|    |:.: |:.......::......:|.|:..|       .||
Frog   199 FYLELYRLIKVEISFKLKGIDLQTMRVRELPDCYVFHNRIIFNNQAHSGKIKLFFESEASVQDCK 263

  Fly   194 QLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVA---LSGYDLVLA---EDEEMNRMIESLKLFD 252
            ..|     :.|...:...:|..|:|. .|:.|:|   |....:|||   :...:|...|..|  .
Frog   264 DWH-----ISGCTQKNTHYILLFDGF-VILTCLASLILCTRSIVLAIKLQKRFVNFFFERYK--R 320

  Fly   253 SICNSK-------WFV 261
            .||:|.       |:|
Frog   321 HICSSDKLEFINGWYV 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G_alpha	14..353	CDD:214595	57/276 (21%)
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	56/270 (21%)
mcoln2	XP_002931739.3	ELD_TRPML	98..265	CDD:425394	33/179 (18%)
mcoln2	XP_002931739.3	PKD_channel	<377..501	CDD:400395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000