DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9953 and Prss16

DIOPT Version :9

Sequence 1:	NP_648067.2	Gene:	CG9953 / 38763	FlyBaseID:	FBgn0035726	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_062302.1	Gene:	Prss16 / 54373	MGIID:	1859181	Length:	509	Species:	Mus musculus

Alignment Length:	506	Identity:	179/506 - (35%)
Similarity:	242/506 - (47%)	Gaps:	46/506 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VGLLLL----GLLAPISGMGFRRGR-----------LTKGF-LGE-PSKIPTLQRSLHSEDLWFE 60
            :|.|||    ||..|  .:..||.|           |..|| ||. |..:|        :..|.|
Mouse     8 LGFLLLVSLWGLSTP--ALLLRRLREHIQKFQESSSLHPGFGLGHGPGAVP--------KQGWLE 62

  Fly    61 QRLDHFKSSDKRTWQQRYFVNADFYRNDSSAPVFLMIGGEGEASAKWMREGAWVHYAEHFGALCL 125
            |.||.|.:||:||:.|||:|| |.:|.....||||.|||||......:..|.....|..:|||.:
Mouse    63 QPLDPFNASDRRTFLQRYWVN-DQHRTGQDVPVFLHIGGEGSLGPGSVMAGHPAALAPAWGALVI 126

  Fly   126 QLEHRFYGKSHPTADLSTENLHYLSSEQALEDLASFVTAMKVKFNLGDGQKWIAFGGSYPGSLAA 190
            .|||||||.|.|...|....|.||||..||.|:||...|:....|:.....||.|||||.||||.
Mouse   127 SLEHRFYGLSMPAGGLDLALLRYLSSRHALADVASARQALSGLLNVSSSSPWICFGGSYAGSLAT 191

  Fly   191 WAREKYPELIYGSISSSGPLLAEVDFKEYFEVVKASLAAY----KPECVDAVTRSFAQVEILLK- 250
            |||.|:|.|::.:::||.||.|.|||..|.:||..||...    ..||:.|.:.:|.:||.||:
Mouse   192 WARLKFPHLVFAAVASSAPLSAVVDFSAYNQVVARSLTQVAIGGSLECLAAASTAFTEVERLLRA 256

  Fly   251 HMIGQRSLDEKFKTCTPIKDSIENDLDMANFFENLAGNFAGVVQYNKDNSPHATITIDDICDVML 315
            ....|..|.|:...|..: |..|:..::....:.|.|   |.|||  |....|.:::..:|.::|
Mouse   257 GPAAQAVLREELGACGSL-DLTEDQAELLGALQALVG---GTVQY--DGQAGAPLSVRQLCGLLL 315

  Fly   316 ----NTTAGPPVTRLGLVNDMLLKESNTTCLDYKYDKMVADMKNVSWDSETAKGMRQWTYQTCHE 376
                |.:...|...|.....::|:.....||.:...:.||.:.|.. ...:..|.|||.||||.|
Mouse   316 GKWGNRSRSTPYLGLRRAVQIVLRSMGQKCLSFSRAETVAQLSNTE-PQVSGVGDRQWLYQTCTE 379

  Fly   377 FGFYQTSDNPADTFGDRFGVDFFIRQCMDVFSKNMNAKFLKLVVSATNDNYGALKPKTTNVLYVH 441
            ||||.|.:.....|.....:.|.:..|..||  .::...:...|:.||..||...|..|.||:|:
Mouse   380 FGFYVTCEGLQCPFSQLPALPFQLELCEQVF--GLSPASVAQAVAQTNSYYGGQSPGATQVLFVN 442

  Fly   442 GSIDPWHALGLVKSTNAALPTIYIEGTAHCANMYEPVKTDPPQLVAARNKI 492
            |..||||.|.:.:....:.|.:.|...:||.:|.....:|.|.|...|.||
Mouse   443 GDTDPWHVLSVTQDLGLSEPALLIPSASHCFDMAPMRPSDSPSLRLGRQKI 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9953	NP_648067.2	Peptidase_S28	61..492	CDD:253262	158/439 (36%)
Prss16	NP_062302.1	Peptidase_S28	63..493	CDD:253262	158/439 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2085
eggNOG	1	0.900	-	-		E1_KOG2182
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3114
Isobase	1	0.950	-	0	Normalized mean entropy	S5466
OMA	1	1.010	-	-		QHG54248
OrthoDB	1	1.010	-	-		D555765at2759
OrthoFinder	1	1.000	-	-		FOG0001283
OrthoInspector	1	1.000	-	-		oto94686
orthoMCL	1	0.900	-	-		OOG6_100644
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2920
SonicParanoid	1	1.000	-	-		X417
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.720