DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9953 and PRSS16

DIOPT Version :9

Sequence 1:	NP_648067.2	Gene:	CG9953 / 38763	FlyBaseID:	FBgn0035726	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_005856.1	Gene:	PRSS16 / 10279	HGNCID:	9480	Length:	514	Species:	Homo sapiens

Alignment Length:	512	Identity:	180/512 - (35%)
Similarity:	250/512 - (48%)	Gaps:	50/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VGLLLL----GLLAPISGMGFRRGRLTKGFLGEPSKIPTLQRSLHSEDL---------------W 58
            :|.|||    |||||.|.:  ||       |||  .|...|.| .::.|               |
Human     9 LGPLLLVSLWGLLAPASLL--RR-------LGE--HIQQFQES-SAQGLGLSLGPGAAALPKVGW 61

  Fly    59 FEQRLDHFKSSDKRTWQQRYFVNADFYRNDSSAPVFLMIGGEGEASAKWMREGAWVHYAEHFGAL 123
            .||.||.|..||:|::.|||:|| |.:......|:||.:||||......:..|.....|..:|||
Human    62 LEQLLDPFNVSDRRSFLQRYWVN-DQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGAL 125

  Fly   124 CLQLEHRFYGKSHPTADLSTENLHYLSSEQALEDLASFVTAMKVKFNLGDGQKWIAFGGSYPGSL 188
            .:.|||||||.|.|...|....|.:|||..||.|:.|...|:...||:.....||.|||||.|||
Human   126 VISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWICFGGSYAGSL 190

  Fly   189 AAWAREKYPELIYGSISSSGPLLAEVDFKEYFEVVKASLAAY----KPECVDAVTRSFAQVEILL 249
            |||||.|:|.||:.|::||.|:.|.:||.||.:||..||.:.    ..||..||:.:||:||..|
Human   191 AAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLECRAAVSVAFAEVERRL 255

  Fly   250 KH-MIGQRSLDEKFKTCTPIKDSIENDLDMANFFENLAGNFAGVVQYNKDNSPHATITIDDICDV 313
            :. ...|.:|..:...|.|: ...||..::....:.|.|   |||||  |....|.:::..:|.:
Human   256 RSGGAAQAALRTELSACGPL-GRAENQAELLGALQALVG---GVVQY--DGQTGAPLSVRQLCGL 314

  Fly   314 ML----NTTAGPPVTRLGLVNDMLLKESNTTCLDYKYDKMVADMKNVSWDSETAKGMRQWTYQTC 374
            :|    |.:...|...|.....::|......||.:...:.||.:::.. ...:..|.|||.||||
Human   315 LLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRSTE-PQLSGVGDRQWLYQTC 378

  Fly   375 HEFGFYQTSDNPADTFGDRFGVDFFIRQCMDVFSKNMNAKFLKLVVSATNDNYGALKPKTTNVLY 439
            .|||||.|.:||...|.....:...:..|..||  .::|..:...|:.||..||...|....||:
Human   379 TEFGFYVTCENPRCPFSQLPALPSQLDLCEQVF--GLSALSVAQAVAQTNSYYGGQTPGANKVLF 441

  Fly   440 VHGSIDPWHALGLVKSTNAALPTIYIEGTAHCANMYEPVKTDPPQLVAARNKILKFL 496
            |:|..||||.|.:.::..::..|:.|...:||.:|.....:|.|.|...|..|.:.|
Human   442 VNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPERPSDSPSLRLGRQNIFQQL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9953	NP_648067.2	Peptidase_S28	61..492	CDD:253262	157/439 (36%)
PRSS16	NP_005856.1	Peptidase_S28	64..494	CDD:253262	157/439 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	246	1.000	Domainoid score	I2176
eggNOG	1	0.900	-	-		E1_KOG2182
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3213
Isobase	1	0.950	-	0	Normalized mean entropy	S5466
OMA	1	1.010	-	-		QHG54248
OrthoDB	1	1.010	-	-		D297753at33208
OrthoFinder	1	1.000	-	-		FOG0001283
OrthoInspector	1	1.000	-	-		otm41351
orthoMCL	1	0.900	-	-		OOG6_100644
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2920
SonicParanoid	1	1.000	-	-		X417
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.720