DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10064 and cfap52

DIOPT Version :9

Sequence 1:	NP_648065.1	Gene:	CG10064 / 38761	FlyBaseID:	FBgn0035724	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001018475.1	Gene:	cfap52 / 553666	ZFINID:	ZDB-GENE-050522-296	Length:	617	Species:	Danio rerio

Alignment Length:	654	Identity:	233/654 - (35%)
Similarity:	359/654 - (54%)	Gaps:	45/654 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DSHDVCRQLLPRAIFGINGKVENGVRQHPVTGSIIFALGNKIGIADYKKNTQEFVAGHTNTISCL 67
            |:.:| .||...|:.|.||.|.:|::.||....:|:.||..:.|...:...|..:.||||.:||:
Zfish     4 DTQEV-PQLGLEAVIGFNGHVFSGLKVHPDKEHLIYPLGCTVIIKSLRSGKQTLLHGHTNNVSCI 67

  Fly    68 DLSKSGKYMASGQINHMGFRGYVIIWNYDQRKEIARHDLHKVSVQAICFTAQDRCVVSIGGVDDG 132
            .:||||:|:||||:..|||:..||||:|::::..||..|||..|:.:.|:..|:.:||:||.||.
Zfish    68 SVSKSGRYIASGQVTFMGFKADVIIWDYEKKEIYARLLLHKAKVEDLSFSPNDKYLVSLGGQDDA 132

  Fly   133 SVIVFDMEAFSPICQTPASRAISGNALTVRPLHNNPYFFVTAGDRHLRLWSILREEKKLYVQDVL 197
            |::|:::|:...||.:|||...:|:.|.:...:.:...||:||:..||:|.:....:|:...:..
Zfish   133 SIVVWNIESKEAICGSPASAQSAGHCLALEYTNLSDEIFVSAGNGTLRVWELDLLNRKIRPTECQ 197

  Fly   198 MASKTRVFYCARINKTDEFAYLGTGTGDIVKIVLNCCDRDHVSKQGSTSCILGAFGTHNPRKPTG 262
            .....|:..|..|...|.:.|.||.:|||:|:        ::..:..:||        .|.|
Zfish   198 TGQLKRIVKCLEIPNDDNYFYCGTTSGDILKV--------NLKTRLLSSC--------GPVK--- 243

  Fly   263 RDCNRYVNGVRALYVLEGGRLLIGAGNGDIELVEERTDVPLINFRDYPGPTWPYLRTLKKTHVSG 327
               .::..||..|.||:.|.:|:|:|:|.:.|...      .||           :|:|...:.|
Zfish   244 ---QKFSKGVNTLKVLKTGDILVGSGDGMLTLCSG------ANF-----------KTIKSVQLEG 288

  Fly   328 RISSF-VRSKTDMFYICTDTNEIYGLNIKTWVLKLLRTCHTKSVYCITFPKNYSGVFATSGKECI 391
            .::|. :|.....||:.|:..::|.|:...:..:|..|.|..:|..:.||...|.:|||.....|
Zfish   289 GVTSVTLRGDGHQFYVGTEAAQMYSLSYTDFKPELTATNHNSAVKDVAFPFGTSELFATCSHNDI 353

  Fly   392 RIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDGIIRAFTPITGRLIYAIPNAHNKGCS 456
            |:|.|...:|||||.|.|..|..:.|..||.||.|.||||.||.|||.:|:|...|.|||:...:
Zfish   354 RVWHSESSKELLRITVPNITCHALGFMRDGRSIFSAWNDGKIRVFTPESGKLKLIIHNAHSMAVT 418

  Fly   457 ALAVASSGRLIVTGGIEGQVRVWKI--DPYRQDLVGVLKDHSGPITSLDINYLDTEVISACTDGS 519
            .:|..:..:.||:||.|||||||:|  |.||  |:..:|:|...:..:.|...|.|.::|.:||:
Zfish   419 TIAATNDCKRIVSGGGEGQVRVWEIFQDSYR--LIETMKEHKATVNCIKIKSNDKECVTASSDGA 481

  Fly   520 CVIWDIKRMTRKQVVTANTQFMSASYFPTGVQVITCGSDGRIIYWMVYNGALIRELTASKKSSVN 584
            |:|||:.|..|.|:|.:||.|....|.|...|:||.|:|.:|.||.||:|:.||||..|...|:|
Zfish   482 CIIWDLVRFVRNQMVLSNTLFSVVCYHPEEYQIITSGTDRKIGYWEVYDGSAIRELEGSLSGSIN 546

  Fly   585 CLAINETGDYFITVGSDLQVKLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIW 649
            .:.|:|.|.||:|.|.|..:|||.|:.|.|..:|..|:.|:.:....|.....|:.|.||:::.|
Zfish   547 GMHISEDGKYFVTGGDDKLLKLWLYSDGEVTHVGIGHSGSITNVRICPNSRYIVSTSADGAILRW 611

  Fly   650 DVPR 653
            ..|:
Zfish   612 RYPQ 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10064	NP_648065.1	WD40	<25..188	CDD:295369	62/162 (38%)
		WD40	33..434	CDD:225201	130/401 (32%)
		WD40 repeat	65..106	CDD:293791	21/40 (53%)
		WD40 repeat	111..151	CDD:293791	15/39 (38%)
		WD40 repeat	159..186	CDD:293791	8/26 (31%)
		WD40	280..652	CDD:225201	140/374 (37%)
		WD40	366..650	CDD:238121	119/285 (42%)
		WD40 repeat	370..407	CDD:293791	16/36 (44%)
		WD40 repeat	412..449	CDD:293791	19/36 (53%)
		WD40 repeat	456..494	CDD:293791	17/39 (44%)
		WD40 repeat	499..535	CDD:293791	13/35 (37%)
		WD40 repeat	541..576	CDD:293791	16/34 (47%)
		WD40 repeat	583..617	CDD:293791	15/33 (45%)
		WD40 repeat	625..651	CDD:293791	6/25 (24%)
cfap52	NP_001018475.1	WD40 repeat	23..58	CDD:293791	9/34 (26%)
		WD40	59..398	CDD:295369	127/377 (34%)
		WD40 repeat	64..106	CDD:293791	21/41 (51%)
		WD40 repeat	112..153	CDD:293791	16/40 (40%)
		WD40 repeat	158..198	CDD:293791	9/39 (23%)
		WD40	164..605	CDD:225201	165/481 (34%)
		WD40 repeat	206..246	CDD:293791	14/61 (23%)
		WD40 repeat	250..282	CDD:293791	13/48 (27%)
		WD40	324..612	CDD:238121	120/289 (42%)
		WD40 repeat	333..371	CDD:293791	16/37 (43%)
		WD40 repeat	372..412	CDD:293791	19/39 (49%)
		WD40 repeat	418..456	CDD:293791	17/39 (44%)
		WD40 repeat	461..489	CDD:293791	10/27 (37%)
		WD40 repeat	497..538	CDD:293791	19/40 (48%)
		WD40 repeat	545..581	CDD:293791	15/35 (43%)
		WD40 repeat	587..613	CDD:293791	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593682
Domainoid	1	1.000	136	1.000	Domainoid score	I4887
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12416
Inparanoid	1	1.050	412	1.000	Inparanoid score	I1824
OMA	1	1.010	-	-		QHG53916
OrthoDB	1	1.010	-	-		D131055at33208
OrthoFinder	1	1.000	-	-		FOG0006987
OrthoInspector	1	1.000	-	-		oto39975
orthoMCL	1	0.900	-	-		OOG6_104302
Panther	1	1.100	-	-	LDO	PTHR13720
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5877
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910