DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10064 and WDR5B

DIOPT Version :9

Sequence 1:NP_648065.1 Gene:CG10064 / 38761 FlyBaseID:FBgn0035724 Length:742 Species:Drosophila melanogaster
Sequence 2:NP_061942.2 Gene:WDR5B / 54554 HGNCID:17826 Length:330 Species:Homo sapiens


Alignment Length:302 Identity:67/302 - (22%)
Similarity:129/302 - (42%) Gaps:15/302 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   357 WVLKLLRTCHTKSVYCITFPKNYSGVFATSGKECIRIWSS--GRKQELLRIMVYNFNCACVRFTH 419
            :.||.....||::|..:.|..|...:.::|....|.||.:  |:.::.|  ..:|...:.|.::.
Human    31 YALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL--YGHNLEISDVAWSS 93

  Fly   420 DGTSIVSVWNDGIIRAFTPITGRLIYAIPNAHNKGCSALAVASSGRLIVTGGIEGQVRVWKIDPY 484
            |.:.:||..:|..::.:...:|:.:..: ..|:.............||::|..:..|::|::...
Human    94 DSSRLVSASDDKTLKLWDVRSGKCLKTL-KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157

  Fly   485 RQDLVGVLKDHSGPITSLDINYLDTEVISACTDGSCVIWDIK--RMTRKQVVTANTQFMSASYFP 547
            :  .:..|..||.|::::..|...:.::|...||.|.|||..  :..:..|...|.......:.|
Human   158 K--CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSP 220

  Fly   548 TGVQVITCGSDGRIIYWMVYNGALIRELTASKKSSVNCLAIN--ETGDYFITVGS-DLQVKLWDY 609
            .|..::|...|..:..|....|..::..|..|.... |:..|  .||..:|..|| |..|.:|:.
Human   221 NGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNL 284

  Fly   610 NSGAVVGIGSEHASSVISCAYSPCMTMFVTGS--TDGSLIIW 649
            .:..:|.....|...|||.|..|...:..:.:  .|.::.:|
Human   285 QTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10064NP_648065.1 WD40 <25..188 CDD:295369
WD40 33..434 CDD:225201 19/78 (24%)
WD40 repeat 65..106 CDD:293791
WD40 repeat 111..151 CDD:293791
WD40 repeat 159..186 CDD:293791
WD40 280..652 CDD:225201 67/302 (22%)
WD40 366..650 CDD:238121 65/293 (22%)
WD40 repeat 370..407 CDD:293791 9/38 (24%)
WD40 repeat 412..449 CDD:293791 6/36 (17%)
WD40 repeat 456..494 CDD:293791 6/37 (16%)
WD40 repeat 499..535 CDD:293791 9/37 (24%)
WD40 repeat 541..576 CDD:293791 6/34 (18%)
WD40 repeat 583..617 CDD:293791 11/36 (31%)
WD40 repeat 625..651 CDD:293791 7/27 (26%)
WDR5BNP_061942.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
WD40 33..326 CDD:238121 66/298 (22%)
WD 1 39..78 10/38 (26%)
WD40 repeat 44..81 CDD:293791 9/38 (24%)
WD 2 81..122 7/41 (17%)
WD40 repeat 87..123 CDD:293791 6/36 (17%)
WD 3 124..164 6/41 (15%)
WD40 repeat 128..164 CDD:293791 5/37 (14%)
WD 4 165..204 11/38 (29%)
WD40 repeat 171..206 CDD:293791 8/34 (24%)
DDB1-binding motif 188..192 2/3 (67%)
WD 5 208..249 7/40 (18%)
WD40 repeat 213..249 CDD:293791 6/35 (17%)
WD 6 252..292 12/40 (30%)
WD40 repeat 257..294 CDD:293791 11/36 (31%)
WD 7 295..330 8/32 (25%)
WD40 repeat 300..326 CDD:293791 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0266
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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