DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10064 and wdr5

DIOPT Version :9

Sequence 1:	NP_648065.1	Gene:	CG10064 / 38761	FlyBaseID:	FBgn0035724	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_998264.1	Gene:	wdr5 / 406372	ZFINID:	ZDB-GENE-040426-2082	Length:	334	Species:	Danio rerio

Alignment Length:	312	Identity:	68/312 - (21%)
Similarity:	129/312 - (41%)	Gaps:	35/312 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 WVLKLLRTCHTKSVYCITFPKNYSGVFATSGKECIRIWSS--GRKQELLRIMVYNFNCACVRFTH 419
            :.||.....|||:|..:.|..:...:.::|..:.|:||.:  |:.::  .|..:....:.|.::.
Zfish    35 YTLKFTLAGHTKAVSSVKFSPSGEWLASSSADKLIKIWGAYDGKFEK--TISGHKLGISDVAWSS 97

  Fly   420 DGTSIVSVWNDGIIRAFTPITGRLIYAIPNAHNKGCSALAVASSGRLIVTGGIEGQVRVWKIDPY 484
            |...:||..:|..::.:...:|:.:..: ..|:.............|||:|..:..||:|.:...
Zfish    98 DSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161

  Fly   485 RQDLVGVLKDHSGPITSLDINYLDTEVISACTDGSCVIWDIKRMTRKQVVTANTQFMS------- 542
            :  .:..|..||.|::::..|...:.::|:..||.|.|||          ||:.|.:.
Zfish   162 K--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD----------TASGQCLKTLIDDDN 214

  Fly   543 -----ASYFPTGVQVITCGSDGRIIYWMVYNGALIRELTASKKSSVNCLAIN--ETGDYFITVGS 600
                 ..:.|.|..::....|..:..|....|..::..|..|.... |:..|  .||..:|..||
Zfish   215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGS 278

  Fly   601 -DLQVKLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGS--TDGSLIIW 649
             |..|.:|:..:..:|.....|...|||.|..|...:..:.:  .|.::.:|
Zfish   279 EDNMVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10064	NP_648065.1	WD40	<25..188	CDD:295369
		WD40	33..434	CDD:225201	18/78 (23%)
		WD40 repeat	65..106	CDD:293791
		WD40 repeat	111..151	CDD:293791
		WD40 repeat	159..186	CDD:293791
		WD40	280..652	CDD:225201	68/312 (22%)
		WD40	366..650	CDD:238121	66/303 (22%)
		WD40 repeat	370..407	CDD:293791	8/38 (21%)
		WD40 repeat	412..449	CDD:293791	6/36 (17%)
		WD40 repeat	456..494	CDD:293791	8/37 (22%)
		WD40 repeat	499..535	CDD:293791	8/35 (23%)
		WD40 repeat	541..576	CDD:293791	5/46 (11%)
		WD40 repeat	583..617	CDD:293791	11/36 (31%)
		WD40 repeat	625..651	CDD:293791	7/27 (26%)
wdr5	NP_998264.1	WD40	37..331	CDD:238121	68/310 (22%)
		WD40 repeat	48..85	CDD:293791	8/38 (21%)
		WD40 repeat	91..127	CDD:293791	6/36 (17%)
		WD40 repeat	132..168	CDD:293791	7/37 (19%)
		WD40 repeat	175..210	CDD:293791	11/44 (25%)
		WD40 repeat	217..253	CDD:293791	5/35 (14%)
		WD40 repeat	261..298	CDD:293791	11/36 (31%)
		WD40 repeat	304..330	CDD:293791	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810