DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10064 and Wdr5b

DIOPT Version :9

Sequence 1:NP_648065.1 Gene:CG10064 / 38761 FlyBaseID:FBgn0035724 Length:742 Species:Drosophila melanogaster
Sequence 2:NP_001019937.1 Gene:Wdr5b / 303907 RGDID:1308567 Length:328 Species:Rattus norvegicus


Alignment Length:306 Identity:65/306 - (21%)
Similarity:130/306 - (42%) Gaps:23/306 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   357 WVLKLLRTCHTKSVYCITFPKNYSGVFATSGKECIRIWSS--GRKQELLRIMVYNFNCACVRFTH 419
            :.|:|....|:.::..:.|..|...:.:::....|.||.:  |:.::.|  ..::...:.|.::.
  Rat    29 YALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTL--YGHSLEISDVAWSS 91

  Fly   420 DGTSIVSVWNDGIIRAFTPITGRLIYAIPNAHNKGCSALAVASS----GRLIVTGGIEGQVRVWK 480
            |.:.:||..:|..::.:...:|:.:..:     ||.|.......    ..|||:|..:..|::|:
  Rat    92 DSSRLVSASDDKTLKLWDVRSGKCLKTL-----KGHSDFVFCCDFNPPSNLIVSGSFDESVKIWE 151

  Fly   481 IDPYRQDLVGVLKDHSGPITSLDINYLDTEVISACTDGSCVIWDIK--RMTRKQVVTANTQFMSA 543
            :...:  .:..|..||.||:::..:...:.::|...||.|.|||..  :..|......|......
  Rat   152 VKTGK--CLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFV 214

  Fly   544 SYFPTGVQVITCGSDGRIIYWMVYNGALIRELTASKKSSVNCL--AINETGDYFITVGS-DLQVK 605
            .:.|.|..::|...|..:..|....|..::..|..|.... |:  :.:.||..::..|| |..|.
  Rat   215 KFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKY-CIFASFSVTGRKWVVSGSEDNMVY 278

  Fly   606 LWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGS--TDGSLIIW 649
            :|:..:..:|.....|...|||.|..|...:..:.:  .|.::.||
  Rat   279 IWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAALENDKTIKIW 324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10064NP_648065.1 WD40 <25..188 CDD:295369
WD40 33..434 CDD:225201 15/78 (19%)
WD40 repeat 65..106 CDD:293791
WD40 repeat 111..151 CDD:293791
WD40 repeat 159..186 CDD:293791
WD40 280..652 CDD:225201 65/306 (21%)
WD40 366..650 CDD:238121 63/297 (21%)
WD40 repeat 370..407 CDD:293791 7/38 (18%)
WD40 repeat 412..449 CDD:293791 6/36 (17%)
WD40 repeat 456..494 CDD:293791 8/41 (20%)
WD40 repeat 499..535 CDD:293791 9/37 (24%)
WD40 repeat 541..576 CDD:293791 6/34 (18%)
WD40 repeat 583..617 CDD:293791 9/36 (25%)
WD40 repeat 625..651 CDD:293791 8/27 (30%)
Wdr5bNP_001019937.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
WD40 31..325 CDD:238121 65/304 (21%)
WD40 <34..325 CDD:225201 63/301 (21%)
WD 1 37..76 7/38 (18%)
WD40 repeat 42..79 CDD:293791 7/38 (18%)
WD 2 79..120 6/45 (13%)
WD40 repeat 85..121 CDD:293791 6/40 (15%)
WD 3 122..162 7/41 (17%)
WD40 repeat 126..162 CDD:293791 6/37 (16%)
WD 4 163..202 11/38 (29%)
WD40 repeat 169..204 CDD:293791 8/34 (24%)
DDB1-binding motif 186..190 2/3 (67%)
WD 5 206..247 7/40 (18%)
WD40 repeat 211..247 CDD:293791 6/35 (17%)
WD 6 250..290 10/40 (25%)
WD40 repeat 255..292 CDD:293791 9/36 (25%)
WD 7 293..328 9/32 (28%)
WD40 repeat 298..324 CDD:293791 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0266
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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