DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10064 and Wdr90

DIOPT Version :9

Sequence 1:	NP_648065.1	Gene:	CG10064 / 38761	FlyBaseID:	FBgn0035724	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_006246128.1	Gene:	Wdr90 / 102555298	RGDID:	7520481	Length:	1894	Species:	Rattus norvegicus

Alignment Length:	743	Identity:	156/743 - (20%)
Similarity:	276/743 - (37%)	Gaps:	182/743 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QLLPRAIFGINGKVENGVRQHPVTGSIIFALGNKIGIADYKKNTQEFVAGHTNTISCLDLSKSGK 74
            ||..:|:.|.||.....:...|.||...:..|..:.:.|....||....||...||.|.|::.|:
  Rat  1230 QLRLKAVVGYNGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGTQRHWLGHPQEISTLALNQDGQ 1294

  Fly    75 YMASGQ-INHMGFRGYVIIWNYDQRKEIARHDL--HKVSVQAICFTAQDRCVVSIGGVDDGSVIV 136
            .:||.. ..:...|..:.||:..|  .:.||.|  |..:|||:.|:..|..:|::|...|.|:.:
  Rat  1295 VLASASCCGNTAARCQIRIWDVPQ--GLCRHLLSHHDTAVQAVAFSPDDEFLVTLGDYADRSLAL 1357

  Fly   137 FDMEAFSPICQTPASRAISGNALTVRPLHNNPY---FFVTAGDRHLRLW-----------SILRE 187
            :.|..:..:..|.....:.|.|.       ||:   ..:..|...:..|           .:.||
  Rat  1358 WSMATYELLSSTRLLEPVHGVAF-------NPWDANELICVGTSAITFWLLQHQGTDTSFQVHRE 1415

  Fly   188 EKKLYVQDVLMASK-TRVFYCARINKTDEFAYLGTGTGDIVKIVLNCCDRDHVSKQGSTSCIL-- 249
            .    |.:.|.||: |.:.|.|     ....|.|:.:|.:       |    |...|:..|.|
  Rat  1416 P----VPEELGASELTSLCYGA-----SPLLYCGSSSGQV-------C----VWDTGTGHCFLAW 1460

  Fly   250 ----GAFGTHNPRKPTGRDCNRYVNGVRALYVLEGGRLLIGAGNGDIELVEERTDVPLINFRDYP 310
                |..|                     :.:..|.||:.|:....:.|
  Rat  1461 EADDGEIG---------------------VLLCSGSRLVSGSNTRRLRL---------------- 1488

  Fly   311 GPTWP--YLRTLKKTHVSGRISS-FVR---------------SKTDMFYICTDTNEIYGLNIKTW 357
               |.  .:..|::...|.|.|| |:.               |..||..:.|....|:.:|....
  Rat  1489 ---WAVGVVPELRRKGSSARSSSVFMERELTLDGAVVSASFDSGMDMGVVGTTAGTIWYVNWTEG 1550

  Fly   358 VLKLLRTCHTKSVYCITFPKNYSGVFATSGKE-CIRIWSSGRKQELLRIMVYNFNCACVRFT--- 418
            ....|.:.|...|..:.|..:.|.. ||.|:: .:|:||....:.:::..|.|.:|.||.:|
  Rat  1551 TSTRLISGHRTKVNEVVFSPSESHC-ATCGEDGSVRVWSLASMELVIQFQVLNQSCLCVAWTPQS 1614

  Fly   419 ---HDGTSIVSVWNDGIIRAFTPITGRLIYAIPNAHNKGCSALAVASSGRLIVTGGIEGQVRVWK 480
               .:...:|:.::||.:|.|: |:...:....:.|....:|:|.::.|:.|::|..:|.|.|
  Rat  1615 CGLPEQQQVVAGYSDGTLRVFS-ISRTALELKMHPHRSALTAIAFSTDGQTILSGDKDGLVAV-- 1676

  Fly   481 IDPYRQDLVGVLKDHSG-PITSL--------DINYLDTEV-ISACTDGSCVIW------------ 523
            ..|.......||.||.| ||:::        |:.....|: ::|..|....||
  Rat  1677 SHPCTGMTFRVLSDHRGAPISAIQSTSKEYGDLGVEGVELWLAASADQRVSIWASDWLRDRCELL 1741

  Fly   524 --------DIKRMTRKQVVTANTQFMS---------------ASYFPTGVQVITC---GSDGRII 562
                    .:.::...:.|..|....:               |::.|....::.|   |:...::
  Rat  1742 EWLSFPAPAVSKVRVPRAVGGNWSLPNSHCFSQAPGLLPPSLAAFCPWDRAILVCVGLGAHEEVV 1806

  Fly   563 YWMVYNGALIRELTASKKSSVNCLAIN---ETGDYFITVG-SDLQVKLWDYNSGAVVGIGSEHAS 623
            :   ||   :|:....:|:.:...|::   ..|...:.|| ::..::|.|..||..... ..|..
  Rat  1807 F---YN---LRQKQVVQKTPLPFFAMSLSLSPGAQLMAVGFAECMLRLLDCVSGTAQDF-EGHDD 1864

  Fly   624 SVISCAYSPCMTMFVTGSTDGSLIIWDV 651
            ||..|.::|...:..| :....:::|:|
  Rat  1865 SVHLCRFTPSGRLLFT-AAHNEILVWEV 1891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10064	NP_648065.1	WD40	<25..188	CDD:295369	42/179 (23%)
		WD40	33..434	CDD:225201	97/449 (22%)
		WD40 repeat	65..106	CDD:293791	12/41 (29%)
		WD40 repeat	111..151	CDD:293791	11/39 (28%)
		WD40 repeat	159..186	CDD:293791	4/40 (10%)
		WD40	280..652	CDD:225201	90/449 (20%)
		WD40	366..650	CDD:238121	69/342 (20%)
		WD40 repeat	370..407	CDD:293791	9/37 (24%)
		WD40 repeat	412..449	CDD:293791	10/42 (24%)
		WD40 repeat	456..494	CDD:293791	11/37 (30%)
		WD40 repeat	499..535	CDD:293791	7/64 (11%)
		WD40 repeat	541..576	CDD:293791	7/52 (13%)
		WD40 repeat	583..617	CDD:293791	8/37 (22%)
		WD40 repeat	625..651	CDD:293791	5/25 (20%)
Wdr90	XP_006246128.1	DUF667	60..236	CDD:282825
		WD40	<456..803	CDD:225201
		WD40	466..828	CDD:295369
		WD40 repeat	473..511	CDD:293791
		WD40 repeat	517..562	CDD:293791
		WD40 repeat	569..609	CDD:293791
		WD40 repeat	614..657	CDD:293791
		WD40	<679..1034	CDD:225201
		WD40 repeat	723..759	CDD:293791
		WD40	758..1058	CDD:295369
		WD40 repeat	764..800	CDD:293791
		WD40 repeat	808..842	CDD:293791
		WD40 repeat	889..923	CDD:293791
		WD40 repeat	949..985	CDD:293791
		WD40 repeat	992..1029	CDD:293791
		WD40	1256..1679	CDD:225201	107/495 (22%)
		WD40	1275..1636	CDD:295369	92/430 (21%)
		WD40 repeat	1285..1327	CDD:293791	13/43 (30%)
		WD40 repeat	1332..1370	CDD:293791	10/37 (27%)
		WD40 repeat	1376..1416	CDD:293791	7/46 (15%)
		WD40 repeat	1426..1461	CDD:293791	11/50 (22%)
		WD40 repeat	1469..1502	CDD:293791	7/51 (14%)
		WD40	1551..1891	CDD:225201	71/351 (20%)
		WD40	1552..1890	CDD:295369	70/349 (20%)
		WD40 repeat	1563..1599	CDD:293791	9/36 (25%)
		WD40 repeat	1606..1647	CDD:293791	9/41 (22%)
		WD40 repeat	1653..1689	CDD:293791	10/37 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910