DRSC/TRiP Functional Genomics Resources

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Protein Alignment sgl and PLCH2

DIOPT Version :9

Sequence 1:NP_476980.1 Gene:sgl / 38760 FlyBaseID:FBgn0261445 Length:476 Species:Drosophila melanogaster
Sequence 2:XP_024306826.1 Gene:PLCH2 / 9651 HGNCID:29037 Length:1755 Species:Homo sapiens


Alignment Length:378 Identity:71/378 - (18%)
Similarity:125/378 - (33%) Gaps:155/378 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 GHQAVEKLSWIYEH-----WIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGAD 243
            |.:.:.:..::.||     |.|.:        .:|.:|:           ||:|:..|.|...::
Human   148 GSKGLVRFYYLDEHRSCIRWRPSR--------KNEKAKI-----------SIDSIQEVSEGRQSE 193

  Fly   244 V--------------------------------SEVAR--AVGL--------------------D 254
            |                                |||||  ..||                    |
Human   194 VFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRD 258

  Fly   255 SRIGSKFLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQV------IDMNEYQKRRFSQK 313
            ..:...|.:|.....||....::|.|::.. |:|||.     |:|      .|.:::|.....::
Human   259 QWLKQTFDEADKNGDGSLSIGEVLQLLHKL-NVNLPR-----QRVKQMFREADTDDHQGTLGFEE 317

  Fly   314 I--IESLFNTVSDKRIAILGFAFKKNTGDT----------RETAAITV--CQTLLEE-------- 356
            .  ...:.:|..|..:.:|.::..|:..|.          ::.|.:|:  ||.::|:        
Human   318 FCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENK 382

  Fly   357 ---------------GAALDIYDPKVEPEQIIDDLTHP----SVTESPEKVKKAVQIHS----DP 398
                           ..|.||::|  |...:..|:|.|    .:|.|........|:.|    |.
Human   383 SKGLLGIDGFTNYTRSPAGDIFNP--EHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDM 445

  Fly   399 YSAVRATHALVICTE---WD----EFV---------DLDFKRIYQSMMKPAYI 435
            |:.|  ..|...|.|   ||    |.:         .:.||.:.:::.|.|:|
Human   446 YAWV--LQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFI 496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sglNP_476980.1 PLN02353 1..459 CDD:177986 71/378 (19%)
PLCH2XP_024306826.1 PH_PLC_eta 136..242 CDD:270170 20/112 (18%)
EFh_PI-PLCeta2 260..400 CDD:320051 24/145 (17%)
EF-hand motif 260..289 CDD:320051 6/29 (21%)
EF-hand motif 296..326 CDD:320051 3/29 (10%)
EF-hand motif 330..358 CDD:320051 4/27 (15%)
EF-hand motif 367..400 CDD:320051 3/32 (9%)
PI-PLCc_eta2 412..814 CDD:176570 21/87 (24%)
C2_PLC_like 844..1054 CDD:175974
Atrophin-1 <1154..1577 CDD:331285
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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