DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sgl and Plcl1

DIOPT Version :9

Sequence 1:NP_476980.1 Gene:sgl / 38760 FlyBaseID:FBgn0261445 Length:476 Species:Drosophila melanogaster
Sequence 2:NP_445908.2 Gene:Plcl1 / 84587 RGDID:708420 Length:1096 Species:Rattus norvegicus


Alignment Length:489 Identity:91/489 - (18%)
Similarity:163/489 - (33%) Gaps:140/489 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 SERIAQWNSDKLPIYEPG--LDEVVKKCRNVNLFFS--TDIETAIKEADLIFISVNTPTKTCGNG 95
            ||:......|.:...:.|  |.:|....|..|.||:  ||::....|          |:|     
  Rat   102 SEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWE----------PSK----- 151

  Fly    96 KGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVR-----------AAESIMHILRANQKPGIH 149
                   |.:|.|.   .:|:...:|.:.|:|...|           .|.||:|        |.:
  Rat   152 -------KDLEKAK---LDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILH--------GEN 198

  Fly   150 Y---DILSNPEFLAEGTAINDLLNADRVLIGGEETP----EGHQAVEKLSWIYEHWIPKQNILTT 207
            |   |:::|...:|     |..::..|.|:...:.|    ||:|...:..|:             
  Rat   199 YESLDLVANSADVA-----NIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWL------------- 245

  Fly   208 NTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGFGGSC 272
                       ...|.|   :.::....:.|.|..::.:.......:|:|..||.:         
  Rat   246 -----------KTVFEA---ADVDGNGIMLEDTSVELIKQLNPTLKESKIRLKFKE--------- 287

  Fly   273 FQKDILNLI----------YICENLNLPEVAAYWQQVIDMNEYQKRRFSQKIIE---SLFNTVSD 324
            .||....|.          ..||....|||.....|:....||.........:|   .:.:...|
  Rat   288 IQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEVEQGVTHVTED 352

  Fly   325 KRIAILGFAFKKNTGDTRETAAIT-VCQTLLEEGAALDIYDPKVEPEQIIDDLTHP------SVT 382
            ..:.|:........|..:...||. ..|.||  ....||:||  |.:::..|:|.|      :.:
  Rat   353 MCLDIIRRYELSEDGRQKGFLAIDGFTQYLL--SPECDIFDP--EQKKVAQDMTQPLSHYYINAS 413

  Fly   383 ESPEKVKKAVQIHSDPYSAVRA----------------THALVICTEWDEFVDLDFKRIYQSMMK 431
            .:...::...:..:|....|||                .:..::|...:..:.|.|:.:.:.:.|
  Rat   414 HNTYLIEDQFRGPADINGYVRALKMGCRSIELDVSDGPDNEPILCNRNNMAMLLSFRSVLEVINK 478

  Fly   432 PAYIFDGRKIL----DHERLQQIGFHVQTIGKKY 461
            .|::.....::    :|..|.|....||.:.|.:
  Rat   479 FAFVASEYPLILCLGNHCSLPQQRVMVQQMKKVF 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sglNP_476980.1 PLN02353 1..459 CDD:177986 90/485 (19%)
Plcl1NP_445908.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..101
Interaction with PPP1C 83..222 34/157 (22%)
PH_PLC_eta 116..224 CDD:270170 32/145 (22%)
EFh_PI-PLC 244..386 CDD:333715 29/179 (16%)
EF-hand motif 244..273 CDD:320029 5/55 (9%)
EF-hand motif 280..312 CDD:320029 8/40 (20%)
EF-hand motif 316..344 CDD:320029 6/27 (22%)
EF-hand motif 353..386 CDD:320029 7/34 (21%)
PI-PLCc_PRIP_metazoa 399..689 CDD:176539 18/114 (16%)
Interaction with GABA A beta subunit 544..568
C2_PLC_like 721..849 CDD:175974
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1096
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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