DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and UGDH

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_005262724.1	Gene:	UGDH / 7358	HGNCID:	12525	Length:	507	Species:	Homo sapiens

Alignment Length:	461	Identity:	317/461 - (68%)
Similarity:	384/461 - (83%)	Gaps:	3/461 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KVCCIGAGYVGGPTCAVMALKCPDIVITLVDKSSERIAQWNSDKLPIYEPGLDEVVKKCRNVNLF 66
            |:|||||||||||||:|:|..||:|.:|:||.:..||..|||..||||||||.|||:.||..|||
Human    19 KICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLF 83

  Fly    67 FSTDIETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVR 131
            |||:|:.|||||||:||||||||||.|.||||||||||:|:.||.|.:.:...|||.||||||||
Human    84 FSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVR 148

  Fly   132 AAESIMHILRANQKPGIHYDILSNPEFLAEGTAINDLLNADRVLIGGEETPEGHQAVEKLSWIYE 196
            |||||..|..||.||.::..:|||||||||||||.||.|.|||||||:|||||.:||:.|..:||
Human   149 AAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE 213

  Fly   197 HWIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSKF 261
            ||:|::.|||||||||||||||||||||||||||||:||:||||||||.|||.|:|:|.|||:||
Human   214 HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKF 278

  Fly   262 LQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQVIDMNEYQKRRFSQKIIESLFNTVSDKR 326
            |:|||||||||||||:|||:|:||.|||||||.|||||||||:||:|||:.:||:||||||:||:
Human   279 LKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKK 343

  Fly   327 IAILGFAFKKNTGDTRETAAITVCQTLLEEGAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKA 391
            ||||||||||:||||||:::|.:.:.|::|||.|.||||||..|||:.||:||.|:|. ::|.:.
Human   344 IAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSED-DQVSRL 407

  Fly   392 VQIHSDPYSAVRATHALVICTEWDEFVDLDFKRIYQSMMKPAYIFDGRKILD--HERLQQIGFHV 454
            |.|..|||.|....||:|||||||.|.:||::||::.|:|||:|||||::||  |..||.|||.:
Human   408 VTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQI 472

  Fly   455 QTIGKK 460
            :|||||
Human   473 ETIGKK 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	314/458 (69%)
UGDH	XP_005262724.1	PLN02353	17..477	CDD:177986	314/458 (69%)
		UDPG_MGDP_dh_N	19..204	CDD:281683	128/184 (70%)
		UDPG_MGDP_dh	227..322	CDD:279344	80/94 (85%)
		UDPG_MGDP_dh_C	345..459	CDD:281682	66/114 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158273
Domainoid	1	1.000	261	1.000	Domainoid score	I1972
eggNOG	1	0.900	-	-		E1_COG1004
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2520
Inparanoid	1	1.050	653	1.000	Inparanoid score	I788
Isobase	1	0.950	-	0	Normalized mean entropy	S2080
OMA	1	1.010	-	-		QHG60954
OrthoDB	1	1.010	-	-		D436314at33208
OrthoFinder	1	1.000	-	-		FOG0002453
OrthoInspector	1	1.000	-	-		oto91855
orthoMCL	1	0.900	-	-		OOG6_100511
Panther	1	1.100	-	-	O	PTHR11374
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6673
SonicParanoid	1	1.000	-	-		X2176
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750