DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and Plcd3

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_690026.2	Gene:	Plcd3 / 72469	MGIID:	107451	Length:	785	Species:	Mus musculus

Alignment Length:	414	Identity:	87/414 - (21%)
Similarity:	136/414 - (32%)	Gaps:	140/414 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 IAQSNKIVVEKSTVPVRAAESI---MHILRA--NQKPGIHYDILSNPE-----FLAEGTAINDLL 169
            ::..|...:|:..|..|...||   |.:.:|  :|.|    :.|.:||     .|.:|..:....
Mouse   424 LSLENHCGLEQQAVMARHLRSILGDMLVTQALDSQNP----EELPSPEQLKGRILVKGKKLPAAR 484

  Fly   170 NAD-RVLIGGEETPEGHQAVEKLSWIYEHWIPKQNILTTNTWSSELSKLAANAFLAQRIS-SINS 232
            :.| |:|...||..|..:..|                       |..:.|.....|::|| .:::
Mouse   485 SEDGRILSDREEEEEEEEEAE-----------------------EALEAAEQRSRAKQISPELSA 526

  Fly   233 LSAVCEATGADVSEVAR------AVG-LDSRIGSKFLQASVGFGGSCFQKD---------ILNLI 281
            |:..|.||.....:.:.      .|| |..|...||.:.:    |:.|.:.         .|.|.
Mouse   527 LAVYCCATRLRTLDPSPGPPQSCTVGSLSERKARKFTREA----GTSFVRHNTQQLTRVYPLGLR 587

  Fly   282 YICENLNLPEVAAYWQ---QVIDMNEYQKRRFSQKIIESLFNTVSDKRIAI---LGFAFKK---- 336
            ....|.|..|:   |.   |::.:|      |.....|...||   .|..|   .|:..|.
Mouse   588 MNSANYNPQEM---WNSGCQLVALN------FQTPGYEMDLNT---GRFLINGQCGYVLKPAYLR 640

  Fly   337 --NT-------GDTRETAAITV--CQTLLEEGAALDIYDPKV---EPEQIIDDLTHPSVTESPEK 387
              ||       |..|.|.||.|  .|.|           ||:   :|..|:|.|..
Mouse   641 QLNTTFDPECPGPPRTTLAIQVLTAQQL-----------PKLNAEKPSSIVDPLVR--------- 685

  Fly   388 VKKAVQIHSDPYSAVRATHALVI------CTEWDEFVDLDFKRIYQSMMKPAYI----------- 435
                |:||..|....:.....|:      |  |::  .|.|:.....::...::
Mouse   686 ----VEIHGVPEDCAQKETDYVLNNGFNPC--WEQ--TLQFRLRAPELVLVRFVVEDYDTTSPND 742

  Fly   436 FDGRKILDHERLQQIGFHVQTIGK 459
            |.|:..|....|:|...|:..:.|
Mouse   743 FVGQSTLPLSSLKQGYRHIHLLSK 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	86/412 (21%)
Plcd3	NP_690026.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		PH_PLC_delta	61..177	CDD:270169
		PH	66..163	CDD:278594
		Substrate binding. /evidence=ECO:0000250	69..97
		EF-hand_10	197..246	CDD:291454
		PLN02228	251..778	CDD:177873	87/414 (21%)
		EF-hand_like	251..332	CDD:286375
		PI-PLCc_delta3	332..627	CDD:176567	52/245 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..517		9/55 (16%)
		C2_PLC_like	656..783	CDD:175974	28/139 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000