DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and plcg2

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001038433.1	Gene:	plcg2 / 561747	ZFINID:	ZDB-GENE-030131-9532	Length:	1240	Species:	Danio rerio

Alignment Length:	515	Identity:	105/515 - (20%)
Similarity:	162/515 - (31%)	Gaps:	194/515 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 GKGRAADL-KYVESAARMIAEIAQSNKIV-------VEKSTVPV----------RAA---ESIMH 138
            |:....|| :|.:|..:...|:.    ||       :|:.||.|          |.|   |.::.
Zfish     3 GRAHQGDLTEYKKSLIKRDLEMG----IVMTVYRQRIERLTVQVIMETRQVAWSRTANKTEGVLD 63

  Fly   139 ILRANQ-KPG----------IHYDILSNPE-----FLAEGTAINDL-LNADRV------LIGGE- 179
            |....: :||          .|.|..::|.     |......:|.| |.||.|      |.|.|
Zfish    64 IFEIREVRPGKNSKEFDRFKDHKDRNTDPNTCFTIFYGSQFVLNTLSLGADSVEDAEKWLTGLEL 128

  Fly   180 --------ETPEGHQAVEKLSWIYEHWIPKQ---------NILTTNTWSSELS----KLAANAFL 223
                    .|||          |.|.|:.||         |.:|.....|.|.    |:....||
Zfish   129 LRDETLAAHTPE----------IIESWLRKQMYSVDQTKKNSITMKELKSLLPQMNFKVPCGRFL 183

  Fly   224 AQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGFGGSCF--QKDILN------L 280
            ..:.:::.:...|                ||.....||..:.:      |  ||.||:      .
Zfish   184 KDKFAALGAKKEV----------------LDFEQFHKFYNSLI------FENQKSILDEFKKETC 226

  Fly   281 IYICENLNLPEVAAYWQQVI----------DMNEYQKRRFSQKIIESLFNTVSDKRIAI---LGF 332
            .:|..|.:.|...:.:|:.:          ::|  |.|......|:......:|....:   |.|
Zfish   227 AFILGNGDQPIQLSDFQRFLLYQQRETWANNLN--QVRELMTIFIDDTMRETNDPAFILEEFLSF 289

  Fly   333 AFKKN---------------------------------TGD----TRETAAITVCQTLLEEGAAL 360
            .|.|.                                 |||    ...|.|...|..|......|
Zfish   290 LFSKENQIWDDKFSEICPLDMNNPLSHYWINSSHNTYLTGDQLRSESSTEAYVRCLRLGCRCVEL 354

  Fly   361 DIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRATHALVICTEWDEFVDLD---- 421
            |.::...||     .:.|.....|..|.|..|:..:| ::...:.:.:|:..|  |..|:.
Zfish   355 DCWNGPEEP-----IIYHGWTRTSKIKFKDVVKAIND-HAFATSEYPVVLSIE--EHCDVKQQKM 411

  Fly   422 ----FKRIYQS--MMKP----------AYIFDGRKILDHERLQQIGFHVQTIGKKYQRTG 465
                ||.::|.  :|:|          .....|:.|:.|::|.    ..||.|:|..|.|
Zfish   412 MAQVFKDVFQDKILMEPLEPEAEQLPSPTQLKGKIIIKHKKLN----IDQTFGRKDLRKG 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	101/507 (20%)
plcg2	NP_001038433.1	PH_PLC_gamma	22..139	CDD:270168	26/120 (22%)
		PI-PLCc_gamma2	307..>442	CDD:176565	26/142 (18%)
		PH-like	469..>497	CDD:302622
		SH2_N-SH2_PLC_gamma_like	516..617	CDD:199829
		SH2_C-SH2_PLC_gamma_like	631..734	CDD:198186
		SH3_PLCgamma2	762..816	CDD:212902
		PH-like	<826..893	CDD:302622
		PI-PLCc_GDPD_SF	<892..1017	CDD:301322
		C2_PLC_like	1044..1169	CDD:175974
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000