DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and plcd1a

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001103170.1	Gene:	plcd1a / 555443	ZFINID:	ZDB-GENE-071004-78	Length:	775	Species:	Danio rerio

Alignment Length:	499	Identity:	92/499 - (18%)
Similarity:	175/499 - (35%)	Gaps:	130/499 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TCAVMALKCPDIVITLVDKSSERIAQWNSDKLPIYEPGLDEVVKKCRNVNLFFSTDIETAIKEAD 79
            :|....||.......:..:.|:.:::.|..::     ||||            ..|::..::..|
Zfish     2 SCPFKPLKRTKSEEFIYQEKSKNVSKENGKRI-----GLDE------------DPDLQFLLRGGD 49

  Fly    80 LIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVRAAESIMHILRANQ 144
            ||.:..|:..||        ..||..|....:   ...|:|....:|:..:...:|:.   ...|
Zfish    50 LIKVKSNSWKKT--------RFLKLNEDCKTI---YQSSSKAFKRESSFELAEIDSVR---LGRQ 100

  Fly   145 KPGIH---YDILSNPEF--LAEGTAINDLLNADRVLIGGEETPEGHQAVEK-LSWIY-------- 195
            ..|:.   |..:.|..|  :.:|..    .|.|.:....:|......::|| ::.::
Zfish   101 SEGLQKYTYSSIENRCFSIIFKGRR----ENLDLIASSDDEANCWVNSLEKVINRLHKLNRQQNS 161

  Fly   196 EHWIPKQNILTTNTWSSELSKLAANAFLAQRISSIN-----SLSAVCEATGA---DVSEVARAVG 252
            ||||.:..........:::|......||.|....:|     :|...|:.:.:   :.||:.....
Zfish   162 EHWIYECMRKADKNADNKMSLKELKHFLRQINIEVNDSYAETLFRKCDTSNSGTLEGSEIKLFYN 226

  Fly   253 LDSR------IGSKFLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQVI---DMNEYQKR 308
            |.::      |..|:..::    |...:.|:||.|.:  ....|....|.:::|   :::|..|:
Zfish   227 LLTQRDEIDVIYDKYATSN----GQMSRNDLLNFIQL--EQREPVSLGYAEELIKKYEVDETAKQ 285

  Fly   309 RFSQKIIESLFNTVSDKRIAILGFAFKKNTGDTRETAAITVCQTLLEEGAALDIYDPKVEPEQII 373
                           ||.::..||....|...|            |...|.:|:|....:|
Zfish   286 ---------------DKHMSKDGFLMYLNQEGT------------LLNPAHIDVYQDMQQP---- 319

  Fly   374 DDLTHPSVTESPEKVKKAVQIH--SDPYSAVRATHALVICTE---WD----EFV---------DL 420
              |.|..::.|........|:.  |...:.::|......|.|   ||    |.|         .:
Zfish   320 --LNHYFISSSHNTYLMEDQLKGPSSTEAYIKALMKSCRCVELDIWDGANGEPVIYYGHTLTSKV 382

  Fly   421 DFKRIYQSMMKPAYIFDGRKIL----DHERLQQ---IGFHVQTI 457
            .||.:.:::...|:......::    :|..|:|   :..|:.||
Zfish   383 PFKDVIKAIKDYAFKASPYPVILSLENHCSLEQQKIVAMHLTTI 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	92/499 (18%)
plcd1a	NP_001103170.1	PH_PLC_delta	44..159	CDD:270169	24/132 (18%)
		PH	44..149	CDD:278594	24/122 (20%)
		EF-hand_10	179..228	CDD:291454	9/48 (19%)
		PLN02952	232..768	CDD:178538	44/234 (19%)
		EF-hand_like	233..313	CDD:286375	21/112 (19%)
		PI-PLCc_delta	313..613	CDD:176535	23/120 (19%)
		C2_PLC_like	645..770	CDD:175974
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000