DRSC/TRiP Functional Genomics Resources

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Protein Alignment sgl and PLCG1

DIOPT Version :9

Sequence 1:NP_476980.1 Gene:sgl / 38760 FlyBaseID:FBgn0261445 Length:476 Species:Drosophila melanogaster
Sequence 2:XP_005260495.1 Gene:PLCG1 / 5335 HGNCID:9065 Length:1330 Species:Homo sapiens


Alignment Length:386 Identity:78/386 - (20%)
Similarity:133/386 - (34%) Gaps:143/386 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 ILSNPEFLAEGTAI-----------NDLLNADRVLIGGEETPEGHQAVEKLSWIYEHWI------ 199
            ||...:.||||:|.           ||:.|:.:..|...|.|..|:      | |.|:.      
Human   459 ILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHE------W-YPHYFVLTSSK 516

  Fly   200 ------------------PKQNILTTNTWSSEL---SKLAA---NAFLAQRISSINSLSAVCEAT 240
                              ||:...:|...|:|.   .||.|   ...:|:|:     |:..|..|
Human   517 IYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERL-----LTEYCIET 576

  Fly   241 GAD-----VSEVARAVG------------LDSRIGSKFLQASVGFGGSCFQKDILNLIYICENL- 287
            ||.     |.|....||            ...||.|:....:..|             ::.:|| 
Human   577 GAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKF-------------FLTDNLV 628

  Fly   288 --NLPEVAAYWQQV-IDMNEYQKRRFSQKIIESLFNTVSDKRIAILGFAFKKNTGDTRE--TAAI 347
              :|.::..::||| :..||:: .|.|:.:.::                   |..:::|  .|::
Human   629 FDSLYDLITHYQQVPLRCNEFE-MRLSEPVPQT-------------------NAHESKEWYHASL 673

  Fly   348 TVCQT------LLEEGAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRATH 406
            |..|.      :..:||.|  ...:.||...       :::...|...|..::..:..:.:... 
Human   674 TRAQAEHMLMRVPRDGAFL--VRKRNEPNSY-------AISFRAEGKIKHCRVQQEGQTVMLGN- 728

  Fly   407 ALVICTEWDEFVDLDFKRIYQSMMKPAYIFDGRKI-----LDHERLQQIGFHVQTIGKKYQ 462
                 :|:|..|||    |......|.|    ||:     ::.|.|::||......|..|:
Human   729 -----SEFDSLVDL----ISYYEKHPLY----RKMKLRYPINEEALEKIGTAEPDYGALYE 776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sglNP_476980.1 PLN02353 1..459 CDD:177986 76/381 (20%)
PLCG1XP_005260495.1 PH_PLC_gamma 29..151 CDD:270168
PH <71..142 CDD:278594
PI-PLCc_gamma 319..>466 CDD:176534 2/6 (33%)
PH-like 489..>523 CDD:302622 7/40 (18%)
SH2_N-SH2_PLC_gamma_like 545..649 CDD:199829 27/121 (22%)
SH2_C-SH2_PLC_gamma_like 663..765 CDD:198186 23/124 (19%)
SH3_PLCgamma1 791..850 CDD:212903
PHsplit_PLC_gamma <864..933 CDD:270054
PLCYc 954..1069 CDD:128454
C2_PLC_like 1087..1250 CDD:175974
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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