DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and PLCL1

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_006217.3	Gene:	PLCL1 / 5334	HGNCID:	9063	Length:	1095	Species:	Homo sapiens

Alignment Length:	396	Identity:	81/396 - (20%)
Similarity:	138/396 - (34%)	Gaps:	143/396 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SSERIAQWNSDKLPIYEPG--LDEVVKKCRNVNLFFS--TDIETAIKEADLIFISVNTPTKTCGN 94
            |.::|:..| |.:...:.|  |.:|....|..|.||:  ||::....|          |:|
Human   101 SEKKISSAN-DCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWE----------PSK---- 150

  Fly    95 GKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVR-----------AAESIMHILRANQKPGI 148
                    |.:|.|.   .:|:...:|.:.|:|...|           .|.||:|        |.
Human   151 --------KDLEKAK---LDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILH--------GE 196

  Fly   149 HY---DILSNPEFLAEGTAINDLLNADRVLIGGEETP----EGHQAVEKLSW---IYEHWIPKQN 203
            :|   |:::|...:|     |..::..|.|:...:.|    ||:|...:..|   ::|......|
Human   197 NYESLDLVANSADVA-----NIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGN 256

  Fly   204 ILTTNTWSSELSK------------------LAANAFLAQRISSINSLSAVCE-ATGADVSEVAR 249
            .:.....|.||.|                  ..:...|..|::......|.|| .|..:|..:..
Human   257 GIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLV 321

  Fly   250 AVG-----LDSRIGSKFLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQVIDMNEYQKRR 309
            .:.     ||:.....||:|..|            :.:|.|::.|..:..|     :::|..:::
Human   322 QISKNKEYLDANDLMLFLEAEQG------------VTHITEDICLDIIRRY-----ELSEEGRQK 369

  Fly   310 -FSQKIIESLFNTVSDKRIAILGFAFKKNTGDTRETAAITVCQTLLEEGAALDIYDPKVEPEQII 373
             |                :||.||.                 |.||  .:..||:||  |.:::.
Human   370 GF----------------LAIDGFT-----------------QYLL--SSECDIFDP--EQKKVA 397

  Fly   374 DDLTHP 379
            .|:|.|
Human   398 QDMTQP 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	81/396 (20%)
PLCL1	NP_006217.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		Interaction with PPP1C	83..222		35/159 (22%)
		PH_PLC_eta	115..223	CDD:270170	32/145 (22%)
		PH	118..223	CDD:278594	32/142 (23%)
		EF-hand_like	315..396	CDD:286375	25/134 (19%)
		PLN02228	330..850	CDD:177873	27/128 (21%)
		PI-PLCc_PRIP_metazoa	398..688	CDD:176539	3/6 (50%)
		Interaction with GABA A beta subunit. /evidence=ECO:0000250	543..567
		C2_PLC_like	720..848	CDD:175974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1066..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000