DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and PLCD1

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001124436.1	Gene:	PLCD1 / 5333	HGNCID:	9060	Length:	777	Species:	Homo sapiens

Alignment Length:	412	Identity:	81/412 - (19%)
Similarity:	134/412 - (32%)	Gaps:	127/412 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 IAQSNKIVVEKSTVPVRAAESIMHILRANQKPGIHYDILSNPE-----FLAEGTAINDLLNADRV 174
            ::..|...:|:..|..|...:|:..:..|:......:.|.:||     .|.:|..:..||..
Human   408 LSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPP--- 469

  Fly   175 LIGGEETPEG------HQAVEKLSWIYEHWI---PKQNILTTNTWSSELSKLAANAFLAQRISSI 230
              |||..||.      .:|.|.........:   ||::.|.                |||.:|
Human   470 --GGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLR----------------LAQELS-- 514

  Fly   231 NSLSAVCEAT-----------GADVSEVA-----RAVGLDSRIGSKFLQASVGFGGSCFQKDILN 279
             .:...|::.           |....|:|     ||:.|....|:.|::.:||.         |:
Human   515 -DMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGH---------LS 569

  Fly   280 LIYICENLNLPEVAAYWQQVIDMNEYQKRRF---SQKIIESLFNTVSDKRIAILGFAFKKNTGDT 341
            .||          .|.|:  .|.:.|.....   ..:|:...|.|...:.....| .|:.|
Human   570 RIY----------PAGWR--TDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQG-RFQDN---- 617

  Fly   342 RETAAITVCQTLLEEGAALD---IYDPKVEPE-----------QIIDDLTHPSVTESPEKV---K 389
                  ..|..:|:.....|   .::|:...:           ::|.....|.|.::...:   |
Human   618 ------GACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPK 676

  Fly   390 KAVQIHSDPYSAVRATHALVICTE------WD-EFV------DLDFKRI----YQSMMKPAYIFD 437
            ..|:||.  .|...|:....:.|.      || ||.      ||...|.    |.:..|..:|
Human   677 VTVEIHG--VSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFI-- 737

  Fly   438 GRKILDHERLQQIGFHVQTIGK 459
            |:..:....|:|...||..:.|
Human   738 GQSTIPLNSLKQGYRHVHLMSK 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	80/410 (20%)
PLCD1	NP_001124436.1	PH_PLC_delta	43..160	CDD:270169
		PH	51..151	CDD:278594
		EF-hand_10	180..229	CDD:291454
		PLN02228	233..776	CDD:177873	81/412 (20%)
		EF-hand_like	234..316	CDD:286375
		PI-PLCc_delta	316..617	CDD:176535	50/254 (20%)
		C2_PLC_like	650..776	CDD:175974	26/114 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000