DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sgl and plcb4

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_021326566.1	Gene:	plcb4 / 407700	ZFINID:	ZDB-GENE-060627-1	Length:	1275	Species:	Danio rerio

Alignment Length:	452	Identity:	81/452 - (17%)
Similarity:	145/452 - (32%)	Gaps:	167/452 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KVCCIGAGYVGGPTCAVMALKCPDIVITLVDKSSERIAQWNSDKLPIYEPGLDEVVK--KCRNV- 63
            ::.|:.:|              ||    ||:.|...:...|:|....:..||..|:.  |..||
Zfish   153 RIICVCSG--------------PD----LVNLSFMYMVTDNTDTAKKWMEGLKSVIHNFKANNVC 199

  Fly    64 ----------NLFFSTDIETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQS 118
                      .|.|.|::...        |.|...|:|.|:||..    |.:..|.:.:.
Zfish   200 PMTCLKKHWMRLSFLTNVNGK--------IPVRGITRTFGSGKTE----KGIFQALKELG----- 247

  Fly   119 NKIVVEKSTVPVRAAESIMHILRANQKPGIHYDIL-SNPEFLAEGTAINDL---LNADRVLIGGE 179
                     :|....:.|.|       ....:||. :..:.:...|.|.:|   :|.|:
Zfish   248 ---------LPSGKNDEIEH-------SAFTFDIFYALTQKICPRTDIEELFKKINGDK------ 290

  Fly   180 ETPEGHQAVEKLSWIYEHWIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADV 244
               ..:..||:|          .:.|..|.....|:::....:.|:|::.|             :
Zfish   291 ---SDYLTVEQL----------VSFLNENQRDPRLNEILFPFYEAKRVTQI-------------I 329

  Fly   245 SEVARAVGLDSRIGSKFLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQVIDMNEYQKRR 309
            .:..|    |:.:..|...:|.||               |..|...|.|..:...:|:.:..:..
Zfish   330 EKYER----DAELKKKGRMSSDGF---------------CRYLMSDENAPVFLDRLDLCQEMEHP 375

  Fly   310 FSQKIIESLFNTVSDKRIAILGFAF-KKNTGDTRETAAITVCQTLLEEGAALDIYDPKVEPEQII 373
            .|...|.|..||.      :.|..| .|::.:......::.|:.:     .||.:|.|.|.::.|
Zfish   376 LSHYFISSSHNTY------LTGRQFGGKSSVEMYRQVLLSGCRCV-----ELDCWDGKGEDQEPI 429

  Fly   374 DDLTHPSVTESPEKVKKAVQIHSDPYSAVRATHALVICTEWDEFVDLDFKRIYQSMMKPAYI 435
                                          .||...:||      |:.||.:.|::.:.|::
Zfish   430 ------------------------------ITHGKAMCT------DILFKDVIQAIRETAFV 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	81/452 (18%)
plcb4	XP_021326566.1	PH_PLC_beta	74..200	CDD:270167	15/64 (23%)
		EFh_PI-PLCbeta4	205..357	CDD:320041	39/235 (17%)
		EF-hand motif	205..234	CDD:320041	8/36 (22%)
		EF-hand motif	240..269	CDD:320041	6/49 (12%)
		EF-hand motif	278..307	CDD:320041	8/47 (17%)
		EF-hand motif	324..357	CDD:320041	10/64 (16%)
		PI-PLCc_beta	369..737	CDD:176533	24/134 (18%)
		C2_PLC_like	771..887	CDD:175974
		DUF1154	978..1020	CDD:310911
		SMC_N	<984..>1219	CDD:330553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000