DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sgl and Plcg2

DIOPT Version :9

Sequence 1:NP_476980.1 Gene:sgl / 38760 FlyBaseID:FBgn0261445 Length:476 Species:Drosophila melanogaster
Sequence 2:NP_058864.1 Gene:Plcg2 / 29337 RGDID:3348 Length:1265 Species:Rattus norvegicus


Alignment Length:490 Identity:80/490 - (16%)
Similarity:154/490 - (31%) Gaps:164/490 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 NSDKLPIYEPGLDEVVKKCRNVNLFFSTDIETAIKEADLIFI---SVNTPTKTCGNGKGRAADLK 103
            |.|.||.||                 .:.|:.|::...::.:   ..:||.:             
  Rat     6 NVDTLPEYE-----------------KSQIKRALELGTVMTVFSARKSTPER------------- 40

  Fly   104 YVESAARMIAEIAQSNKIVVEKSTVPVRAAESIMHILRANQKPGIHYDILSNPEFLAEGTAINDL 168
                  |.:..|.::.::...|:...:.....||.|...  :||      .|.:......|:...
  Rat    41 ------RTVQMIMETRQVAWSKTADKIEGFLDIMEIKEI--RPG------KNSKDFERAKAVRHK 91

  Fly   169 LNADRVLIGGEE---------TPEGHQAVEKLSWI---------------YEHWIPKQNILTTNT 209
            .:....:..|.:         |.....||:.||.:               .|.|:.||......|
  Rat    92 ADCCFTIFYGTQFVLSTLSLATDSKEDAVKWLSGLKILHQEAMNASTPTMIESWLRKQIYSVDQT 156

  Fly   210 WSSELSKLAANAFLAQ---RISSINSLSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGFGGS 271
            ..:.:|.......|..   ::|.|..|.......||...|::            |.|..:.:...
  Rat   157 RRNSISLRELKTILPLVNFKVSGIKFLKDKLVEIGAQKDELS------------FEQFHLFYKKL 209

  Fly   272 CF--QKDIL------NLIYICENLNLPEVAA----------------YWQQVIDMNEYQKRRFSQ 312
            .|  ||.||      :.::|..|.:.|:.:|                .|.|  |:|:.::|  ..
  Rat   210 MFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQELWAQ--DLNKVRER--MT 270

  Fly   313 KIIESLFNTVSDKRIAI---LGFAFKKNTGDTRETAAITVCQTLLEEGAALDIYDPK---VEPEQ 371
            |.|:......::..:.:   |.:.|      :||.:                |:|.|   |:.:.
  Rat   271 KFIDDTMRETAEPFLFVDEFLTYLF------SRENS----------------IWDEKYDAVDMQD 313

  Fly   372 IIDDLTHPSVTESPEKVKKAVQIHSDPYSA--VRATHALVICTE----------------WDEFV 418
            :.:.|:|..::.|........|:.|:..:.  :|...|...|.|                |....
  Rat   314 MNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTRTT 378

  Fly   419 DLDFKRIYQSMMKPAYIFDGRKIL----DHERLQQ 449
            .:.|..:.|::...|::.....::    :|..::|
  Rat   379 KIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQ 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sglNP_476980.1 PLN02353 1..459 CDD:177986 80/490 (16%)
Plcg2NP_058864.1 PH_PLC_gamma 22..140 CDD:270168 18/144 (13%)
PH-like 235..>276 CDD:302622 9/44 (20%)
PI-PLCc_gamma 311..>458 CDD:176534 15/103 (15%)
PH-like 475..>510 CDD:302622
SH2_N-SH2_PLC_gamma_like 527..627 CDD:199829
SH2_C-SH2_PLC_gamma_like 641..744 CDD:198186
SH3_PLCgamma2 773..827 CDD:212902
PHsplit_PLC_gamma <840..910 CDD:270054
PI-PLCc_GDPD_SF <926..1031 CDD:301322
C2_PLC_like 1061..1187 CDD:175974
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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