DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and Plcb4

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_006235145.1	Gene:	Plcb4 / 25031	RGDID:	3345	Length:	1206	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	98/483 - (20%)
Similarity:	159/483 - (32%)	Gaps:	162/483 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PTCAVMALKCPDIVITLVDKSSERIAQWNSDK-------LPIYEPGLDEVVKKCRNVNLFFSTDI 71
            |...|:|..|...||:         .|:.|||       :.:|....|.:.|:.| ..:..:..:
  Rat   706 PVDGVIAATCSVQVIS---------GQFLSDKKIGTYVEVDMYGLPTDTIRKEFR-TRMVMNNGL 760

  Fly    72 ETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVRAAES- 135
            .....|...:|..|..|            ||     |...||....:||::.:: .:|:...::
  Rat   761 NPVYNEESFVFRKVILP------------DL-----AVLRIAVYDDNNKLIGQR-ILPLDGLQAG 807

  Fly   136 IMHILRANQ--KPGIHYDILSNPEFLAEGTAINDLLNADRVLIGGEETPEGH-QAVEKLSWIYEH 197
            ..||...|:  ||      ||.|....     |.:|..        ..|:|. ..|:.||
  Rat   808 YRHISLRNEGNKP------LSLPTIFC-----NIVLKT--------YVPDGFGDIVDALS----- 848

  Fly   198 WIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSK-- 260
             .||:.:..|...:.::                       .|.|.:.|::|......|:...|
  Rat   849 -DPKKFLSITEKRADQM-----------------------RAMGIETSDIADVPSDTSKNDKKGK 889

  Fly   261 ------------------FLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYW----QQVIDMN 303
                              ...|::|.|...  |..:.||......:|.::.||.    :|..::|
  Rat   890 ANPAKANVTPQSSSELRPTTTAALGSGQEA--KKGIELIPQVRIEDLKQMKAYLKHLKKQQKELN 952

  Fly   304 EYQKRRFSQ-KIIESLFNTVSDKRIA-----------ILGFAFKKNTGDTRETAAITVCQTLLEE 356
            ..:|:...: ..::.|..|..||.:|           ||..|.||..|..
  Rat   953 SLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSN--------------- 1002

  Fly   357 GAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRATHALVICTEWDEFVDLD 421
              .|:|   |.|.|..|..||    ::...|||:.|..|:..:|.:..||:    .|..|..||.
  Rat  1003 --CLEI---KKETEIKIQTLT----SDHKSKVKEIVAQHTKEWSEMINTHS----AEEQEIRDLH 1054

  Fly   422 FKRIYQSMMKPAYIFDGRKILDHERLQQ 449
            ..:..:.:         ||:|.:...||
  Rat  1055 LSQQCELL---------RKLLINAHEQQ 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	98/483 (20%)
Plcb4	XP_006235145.1	PH_PLC_beta	17..143	CDD:270167
		EFh_PI-PLCbeta4	148..300	CDD:320041
		EF-hand motif	148..177	CDD:320041
		EF-hand motif	183..211	CDD:320041
		EF-hand motif	221..250	CDD:320041
		EF-hand motif	267..300	CDD:320041
		PI-PLCc_beta	312..680	CDD:176533
		C2_PLC_like	714..830	CDD:175974	31/154 (20%)
		PTZ00121	<859..1206	CDD:173412	54/277 (19%)
		DUF1154	926..967	CDD:399553	7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000