DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and PLCB1

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_056007.1	Gene:	PLCB1 / 23236	HGNCID:	15917	Length:	1216	Species:	Homo sapiens

Alignment Length:	171	Identity:	42/171 - (24%)
Similarity:	64/171 - (37%)	Gaps:	36/171 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 YIC------ENLNLPEVAAYWQQVIDMNEYQKRRFSQKIIESLFNTV--------SDKRIAILGF 332
            |||      :.|.||.|..|    |::.:|....::. :||:|.|.:        ..|::|.|..
Human   773 YICLRNERNQPLTLPAVFVY----IEVKDYVPDTYAD-VIEALSNPIRYVNLMEQRAKQLAALTL 832

  Fly   333 ----AFKK--NTGDTRETAAITVCQTLLEEGA-ALDIYDPKVEPEQIIDDLTHPSVTESPEKVKK 390
                ..||  :.|:|...|......|..|.|. ......|| .|.|.:.....|...::|.|.:.
Human   833 EDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPK-PPSQALHSQPAPGSVKAPAKTED 896

  Fly   391 AVQIHSDPYSAVRATHALVI--CTEWDEFVDLDFKRIYQSM 429
            .:|      |.:....|..|  ..:...||.|. |:.|:.|
Human   897 LIQ------SVLTEVEAQTIEELKQQKSFVKLQ-KKHYKEM 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	42/171 (25%)
PLCB1	NP_056007.1	PH_PLC_beta	22..148	CDD:270167
		EFh_PI-PLCbeta1	153..303	CDD:320038
		EF-hand motif	153..182	CDD:320038
		EF-hand motif	186..215	CDD:320038
		EF-hand motif	224..253	CDD:320038
		EF-hand motif	270..303	CDD:320038
		PI-PLCc_beta	316..643	CDD:176533
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..534
		C2_PLC_like	677..796	CDD:175974	9/26 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..891		13/57 (23%)
		DUF1154	903..939	CDD:369010	8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	963..994
		PLC-beta_C	1003..1172	CDD:370077
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1071..1095
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1173..1216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000