DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and Plcd1

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001280577.1	Gene:	Plcd1 / 18799	MGIID:	97614	Length:	782	Species:	Mus musculus

Alignment Length:	355	Identity:	83/355 - (23%)
Similarity:	118/355 - (33%)	Gaps:	89/355 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LSNPEFLAE-----GTAINDLLNADRVLIGGEETPEG------HQAVEKLSWIYEHWI---PKQN 203
            |.:||.|.|     |..:..||.|     |||..||.      .:|.|.........:   ||::
Mouse   451 LPSPEQLKEKILLKGKKLGGLLPA-----GGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKED 510

  Fly   204 ILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGF 268
            .|......|::.....:.......|...|..|..|.  |..|| :||:.|....|:.|::.:||.
Mouse   511 KLKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEM--ASFSE-SRALRLLQESGNSFVRHNVGH 572

  Fly   269 GGSCFQKDILNLIYICENLNLPEVAAYWQQVIDMNEYQKRRF---SQKIIESLFNTVSDKRIAIL 330
                     |:.||          .|.|:  .|.:.|.....   ..:|:...|.|...:....|
Mouse   573 ---------LSRIY----------PAGWR--TDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYL 616

  Fly   331 GFAFKKNTG-------------DTRETAAITVCQTLLEEGAALDIYDPKVEPEQIIDDLTHPSVT 382
            | .|:.|.|             ||      |.....|.:|   ..:.||.....||.....|.|.
Mouse   617 G-CFQDNGGCGYVLKPAFLRDPDT------TFNSRALTQG---PWWAPKKLRVWIISGQQLPKVN 671

  Fly   383 ESPEKV---KKAVQIHSDPYSAVRATHALV----ICTEWD---EFV----DLDFKRI----YQSM 429
            ::...:   |..|:||...........|::    ....||   |||    ||...|.    |.|.
Mouse   672 KNKNSIVDPKVIVEIHGVGQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSS 736

  Fly   430 MKPAYIFDGRKILDHERLQQIGFHVQTIGK 459
            .|..:|  |:..:....|:|...||..:.|
Mouse   737 SKNDFI--GQSTIPWNSLKQGYRHVHLLSK 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	82/353 (23%)
Plcd1	NP_001280577.1	PH_PLC_delta	48..165	CDD:270169
		PH	56..155	CDD:278594
		EF-hand_10	185..234	CDD:291454
		PLN02952	239..777	CDD:178538	83/355 (23%)
		EF-hand_like	239..321	CDD:286375
		PI-PLCc_delta	321..622	CDD:176535	47/200 (24%)
		C2_PLC_like	654..781	CDD:175974	29/113 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000