DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and Plcb4

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_006498999.1	Gene:	Plcb4 / 18798	MGIID:	107464	Length:	1207	Species:	Mus musculus

Alignment Length:	483	Identity:	99/483 - (20%)
Similarity:	159/483 - (32%)	Gaps:	162/483 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PTCAVMALKCPDIVITLVDKSSERIAQWNSDK-------LPIYEPGLDEVVKKCRNVNLFFSTDI 71
            |...|:|..|...||:         .|:.|||       :.:|....|.:.|:.| ..:..:..:
Mouse   707 PVDGVIAATCSVQVIS---------GQFLSDKKIGTYVEVDMYGLPTDTIRKEFR-TRMVMNNGL 761

  Fly    72 ETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVRAAES- 135
            .....|...:|..|..|            ||     |...||....:||::.:: .:|:...::
Mouse   762 NPVYNEESFVFRKVILP------------DL-----AVLRIAVYDDNNKLIGQR-ILPLDGLQAG 808

  Fly   136 IMHILRANQ--KPGIHYDILSNPEFLAEGTAINDLLNADRVLIGGEETPEGH-QAVEKLSWIYEH 197
            ..||...|:  ||      ||.|....     |.:|..        ..|:|. ..|:.||
Mouse   809 YRHISLRNEGNKP------LSLPTIFC-----NIVLKT--------YVPDGFGDIVDALS----- 849

  Fly   198 WIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSK-- 260
             .||:.:..|...:.::                       .|.|.:.|::|......|:...|
Mouse   850 -DPKKFLSITEKRADQM-----------------------RAMGIETSDIADVPSDTSKNDKKGK 890

  Fly   261 ------------------FLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYW----QQVIDMN 303
                              ...|::|.|...  |..:.||......:|.::.||.    :|..::|
Mouse   891 ANPAKANVTPQSSSELRPTTTAALGSGQEA--KKGIELIPQVRIEDLKQMKAYLKHLKKQQKELN 953

  Fly   304 EYQKRRFSQ-KIIESLFNTVSDKRIA-----------ILGFAFKKNTGDTRETAAITVCQTLLEE 356
            ..:|:...: ..::.|..|..||.:|           ||..|.||..|..
Mouse   954 SLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSN--------------- 1003

  Fly   357 GAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRATHALVICTEWDEFVDLD 421
              .|:|   |.|.|..|..||    |:...|||:.|..|:..:|.:..||:    .|..|..||.
Mouse  1004 --CLEI---KKETEIKIQTLT----TDHKSKVKEIVAQHTKEWSEMINTHS----AEEQEIRDLH 1055

  Fly   422 FKRIYQSMMKPAYIFDGRKILDHERLQQ 449
            ..:..:.:         ||:|.:...||
Mouse  1056 LSQQCELL---------RKLLINAHEQQ 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	99/483 (20%)
Plcb4	XP_006498999.1	PH_PLC_beta	17..143	CDD:270167
		EFh_PI-PLCbeta4	148..300	CDD:320041
		EF-hand motif	148..177	CDD:320041
		EF-hand motif	183..211	CDD:320041
		EF-hand motif	221..250	CDD:320041
		EF-hand motif	267..300	CDD:320041
		PI-PLCc_beta	312..681	CDD:176533
		C2_PLC_like	715..831	CDD:175974	31/154 (20%)
		PTZ00121	<860..1207	CDD:173412	55/277 (20%)
		DUF1154	927..968	CDD:399553	7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000